Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | SCN4A | P35499 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 3/20 | 0.38 |
| ▸ | CTSC | P53634 | 2/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 3/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 2/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.36 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7289268 | 0.93 | HTR2C (0.38) | ELANESCN4ADPP4CTSCHRH2 | |
| SCHEMBL6922149 | 0.91 | MEN1 (0.35) | ELANESCN4AHRH2HRH1NOS2 | |
| SCHEMBL168919 | 0.82 | ELANE (0.54) | ELANESCN4ADPP4CTSCHTR2C | |
| SCHEMBL20482434 | 0.82 | ELANE (0.54) | ELANESCN4ADPP4CTSCHTR2C | |
| SCHEMBL20482162 | 0.82 | ELANE (0.54) | ELANESCN4ADPP4CTSCHTR2C | |
| SCHEMBL27623273 | 0.81 | ELANE (0.43) | ELANESCN4AHRH2HRH1HTR2C | |
| SCHEMBL18589371 | 0.79 | MGLL (0.44) | ELANEHTR2C | |
| SCHEMBL7416214 | 0.79 | HSD11B1 (0.44) | ELANESCN4AHRH2HRH1 | |
| SCHEMBL18607990 | 0.79 | MGLL (0.44) | ELANEHTR2C | |
| SCHEMBL28322880 | 0.79 | MEN1 (0.54) | ELANESCN4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2431357-A2 | 3-Aminopyrrolidine Derivatives as Modulators of Chemokine Receptors | Incyte Corporation (US) | 2012-03-21 | — | — | EP | claimed |