Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 5/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.33 |
| ▸ | CTSA | P10619 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9787409 | 0.84 | P2RX7 (0.43) | P2RX7GRM5RAB9ACTSACYP1A2 | |
| SCHEMBL7439990 | 0.78 | BTK (0.46) | MMP13ADAM17CYP1A2MAPT | |
| SCHEMBL6424145 | 0.76 | P2RX7 (0.47) | P2RX7GRM5RAB9ACYP1A2MAPT | |
| SCHEMBL1958309 | 0.76 | P2RX7 (0.62) | P2RX7GRM5RAB9ACTSACYP1A2 | |
| SCHEMBL7435134 | 0.75 | KMT2A (0.50) | RAB9AMAPT | |
| SCHEMBL6279299 | 0.70 | P2RX7 (0.47) | P2RX7GRM5RAB9ACYP1A2AHR | |
| SCHEMBL22061926 | 0.70 | P2RX7 (0.55) | P2RX7GRM5RAB9ACYP1A2CCR1 | |
| SCHEMBL2237588 | 0.68 | P2RX7 (0.62) | P2RX7GRM5RAB9ACTSACYP1A2 | |
| SCHEMBL7487387 | 0.68 | ALDH1A1 (0.48) | RAB9ACYP1A2MAPT | |
| SCHEMBL11454469 | 0.68 | CNR2 (0.58) | P2RX7GRM5RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4405628-A | 4-Pyridylimidazolones and method of use | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-09-20 | — | — | US | disclosed |