Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7448280 | 0.94 | ALDH1A1 (0.31) | ALDH1A1HPGDKMT2A | |
| SCHEMBL7438299 | 0.94 | ESR1 (0.35) | ALDH1A1HPGDKMT2AESR1ESR2 | |
| SCHEMBL7449766 | 0.92 | ALDH1A1 (0.33) | ALDH1A1HPGDKMT2A | |
| SCHEMBL7438155 | 0.92 | CCR5 (0.30) | ALDH1A1HPGDKMT2A | |
| SCHEMBL7444161 | 0.92 | HSD17B2 (0.32) | ALDH1A1HPGDKMT2A | |
| SCHEMBL7442143 | 0.91 | — | — | |
| SCHEMBL7444893 | 0.90 | MAPT (0.37) | KMT2AESR1ESR2 | |
| SCHEMBL7439799 | 0.89 | ADAMTS4 (0.31) | — | |
| SCHEMBL7436844 | 0.87 | ALDH1A1 (0.32) | ALDH1A1HPGDKMT2A | |
| SCHEMBL7449838 | 0.87 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0668860-B1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | UPJOHN CO (US) | 2002-09-11 | — | — | EP | claimed |
| WO-1994011361-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | THE UPJOHN COMPANY (US) | 1994-05-26 | — | — | WO | claimed |
| EP-1203770-A1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | PHARMACIA & UPJOHN COMPANY (US) | 2002-05-08 | — | — | EP | disclosed |
| WO-1994011361-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | THE UPJOHN COMPANY (US) | 1994-05-26 | — | — | WO | disclosed |