Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | GLS | O94925 | 3/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | CCKBR | P32239 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | FPR3 | P25089 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL184425 | 0.81 | NR1H4 (0.61) | BRD4NAMPTHDAC1GLSNR1H4 | |
| SCHEMBL3509267 | 0.80 | BRD4 (0.52) | BRD4NAMPTHDAC1GLSHIF1A | |
| SCHEMBL13135999 | 0.78 | GLS (0.50) | BRD4NAMPTHDAC1GLSNR1H4 | |
| SCHEMBL11090977 | 0.78 | NAMPT (0.53) | BRD4NAMPTHDAC1NPSR1HDAC6 | |
| SCHEMBL21455594 | 0.77 | NR1H4 (0.48) | BRD4NAMPTHDAC1GLSNR1H4 | |
| SCHEMBL26508960 | 0.77 | BRD4 (0.52) | BRD4NAMPTHDAC1GLSCCKBR | |
| SCHEMBL31044413 | 0.77 | GLS (0.49) | BRD4NAMPTHDAC1GLSNR1H4 | |
| SCHEMBL879574 | 0.77 | LOXL2 (0.56) | BRD4NAMPTGLSNR1H4HIF1A | |
| SCHEMBL24140014 | 0.76 | ALDH1A1 (0.49) | BRD4NAMPTHDAC1GLSNR1H4 | |
| SCHEMBL20474743 | 0.76 | HDAC6 (0.56) | NAMPTHDAC1GLSNR1H4HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1240154-A1 | SERINE PROTEASE INHIBITORS | Tularik Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001044226-A1 | SERINE PROTEASE INHIBITORS | TULARIK LIMITED (GB) | 2001-06-21 | — | — | WO | disclosed |