Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | HTR1D | P28221 | 4/20 | 0.52 |
| ▸ | HTR1B | P28222 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435180 | 0.91 | HTR1D (0.62) | FYNDRD3HTR1DHTR1BCYP2D6 | |
| SCHEMBL7441326 | 0.90 | HTR1D (0.58) | FYNDRD3HTR1DHTR1BALDH1A1 | |
| SCHEMBL7443837 | 0.87 | HTR1D (0.59) | FYNDRD3HTR1DHTR1B | |
| SCHEMBL7443957 | 0.87 | HTR1D (0.48) | FYNDRD3HTR1DHTR1B | |
| SCHEMBL7442744 | 0.75 | HTR1D (0.81) | HTR1DHTR1B | |
| SCHEMBL7441299 | 0.74 | HTR1D (0.53) | FYNDRD3HTR1DHTR1BHTR1A | |
| SCHEMBL7439287 | 0.73 | HTR1D (0.49) | DRD3HTR1DHTR1BHTR1A | |
| SCHEMBL7447452 | 0.72 | DRD2 (0.55) | DRD3HTR1DHTR1BHTR1A | |
| SCHEMBL7447457 | 0.72 | DRD2 (0.55) | DRD3HTR1DHTR1BHTR1A | |
| SCHEMBL8693035 | 0.72 | FYN (0.70) | FYNDRD3ALDH1A1CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0690843-B1 | Formyl- or cyano- substituted indole derivatives having dopaminergic activity | UPJOHN CO (US) | 2000-08-30 | — | — | EP | disclosed |
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0690843-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |