Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 3/20 | 0.49 |
| ▸ | HTR1B | P28222 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 9/20 | 0.45 |
| ▸ | DRD3 | P35462 | 7/20 | 0.45 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 5/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7439062 | 0.73 | FYN (0.54) | HTR1DHTR1BDRD3HTR1A | |
| SCHEMBL7450639 | 0.72 | OPRM1 (0.37) | HTR1DHTR1B | |
| SCHEMBL8689156 | 0.71 | DRD2 (0.58) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL1792787 | 0.70 | GRIN2B (0.61) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL6561200 | 0.69 | DRD2 (0.52) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL8692261 | 0.69 | DRD2 (0.78) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL7434490 | 0.69 | HTR1D (0.81) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL7435180 | 0.69 | HTR1D (0.62) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL8688541 | 0.68 | DRD2 (0.56) | HTR1DHTR1BDRD2DRD3DRD4 | |
| SCHEMBL7441326 | 0.68 | HTR1D (0.58) | HTR1DHTR1BDRD2DRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0690843-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |