Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8386890 | 0.78 | MAPK1 (0.41) | GRM5GRM1POLBFNTAFNTB | |
| SCHEMBL7436707 | 0.72 | GSK3B (0.43) | GSK3BGRM5GRM1LMNAALDH1A1 | |
| SCHEMBL16088741 | 0.72 | HSD17B10 (0.57) | GSK3BSIGMAR1LMNAALDH1A1L3MBTL1 | |
| Bromide SCHEMBL3869963 | 0.71 | MAPT (0.44) | GSK3BGRM5GRM1LMNAALDH1A1 | |
| SCHEMBL12700339 | 0.70 | LMNA (0.58) | GSK3BSIGMAR1LMNAALDH1A1POLB | |
| SCHEMBL31036675 | 0.70 | GSK3B (0.41) | GSK3BSIGMAR1LMNAPOLBCA1 | |
| SCHEMBL7444588 | 0.69 | GSK3B (0.43) | GSK3BSIGMAR1LMNAALDH1A1L3MBTL1 | |
| SCHEMBL1515793 | 0.69 | MAPT (0.61) | GSK3BSIGMAR1LMNAL3MBTL1POLB | |
| SCHEMBL28043310 | 0.69 | KMT2A (0.65) | GSK3BLMNAALDH1A1L3MBTL1POLB | |
| SCHEMBL20378480 | 0.68 | HTT (0.40) | LMNAALDH1A1L3MBTL1RAB9ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0849263-A2 | Pharmaceutical substituted propanoic acid derivatives | ELI LILLY AND COMPANY LIMITED (GB) | 1998-06-24 | — | — | EP | disclosed |