Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 9/20 | 0.56 |
| ▸ | NPY1R | P25929 | 3/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11448671 | 0.90 | LTA4H (0.68) | LTA4HNPY1RAURKBCHEK2SSTR2 | |
| SCHEMBL7438835 | 0.89 | KMT2A (0.57) | LTA4HKMT2ACHEK2 | |
| SCHEMBL7445314 | 0.88 | LTA4H (0.56) | LTA4HKMT2ACHEK2PSEN1PSEN2 | |
| SCHEMBL7446075 | 0.86 | LTA4H (0.75) | LTA4HNPY1RAURKBSSTR2 | |
| SCHEMBL11447734 | 0.86 | LTA4H (0.67) | LTA4HNPY1R | |
| SCHEMBL7447377 | 0.83 | LTA4H (0.56) | LTA4HNPY1RAURKBCHEK2 | |
| SCHEMBL7447210 | 0.82 | LTA4H (0.45) | LTA4HKMT2ACHEK2 | |
| SCHEMBL7444871 | 0.81 | LTA4H (0.56) | LTA4HNPY1RAURKBKMT2ACHEK2 | |
| SCHEMBL7347261 | 0.77 | LTA4H (0.54) | LTA4HCHEK2 | |
| SCHEMBL2185418 | 0.76 | LTA4H (0.50) | LTA4HNPY1RCHEK2SSTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763021-A1 | PHENOXYALKYL SUBSTITUTED PIPERIDINES, PYRROLIDINES, MORPHOLINES AND TIOMORPHOLINES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-03-19 | — | — | EP | claimed |
| WO-1995033722-A1 | PHENOXYALKYL SUBSTITUTED PIPERIDINES, PYRROLIDINES, MORPHOLINES AND TIOMORPHOLINES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-12-14 | — | — | WO | claimed |
| EP-0763021-A1 | PHENOXYALKYL SUBSTITUTED PIPERIDINES, PYRROLIDINES, MORPHOLINES AND TIOMORPHOLINES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-03-19 | — | — | EP | disclosed |
| WO-1995033722-A1 | PHENOXYALKYL SUBSTITUTED PIPERIDINES, PYRROLIDINES, MORPHOLINES AND TIOMORPHOLINES AS CALCIUM CHANNEL ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-12-14 | — | — | WO | disclosed |