Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 19/20 | 0.77 |
| ▸ | HTR1A | P08908 | 2/20 | 0.77 |
| ▸ | HTR1D | P28221 | 2/20 | 0.77 |
| ▸ | HTR1B | P28222 | 2/20 | 0.77 |
| ▸ | HTR1F | P30939 | 2/20 | 0.77 |
| ▸ | HTR7 | P34969 | 2/20 | 0.77 |
| ▸ | DRD3 | P35462 | 2/20 | 0.77 |
| ▸ | DRD2 | P14416 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7439766 | 0.95 | HTR6 (0.85) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| Oxalic Acid SCHEMBL7433685 | 0.93 | HTR6 (0.90) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL739877 | 0.87 | HTR6 (1.00) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| Trifluoroacetic Acid SCHEMBL4019041 | 0.84 | HTR6 (0.82) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL3611374 | 0.82 | HTR6 (0.80) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| Hydrochloric Acid SCHEMBL3624923 | 0.81 | HTR6 (0.78) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL27642788 | 0.80 | HTR6 (0.76) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL4023837 | 0.80 | HTR6 (0.76) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL261059 | 0.80 | HTR6 (0.67) | HTR6HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL4020191 | 0.80 | HTR6 (0.71) | HTR6HTR1AHTR1DHTR1BHTR1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187805-B1 | TREATING CONDITION FOR WHICH SELECTIVE AGONISM OR ANTAGONISM OF 5-HT-6 RECEPTORS IS INDICATED BY ADMINISTERING COMPOUNDS SUCH AS N,N-DIMETHYL 2-(1-(BENZENESULPHONYL)-5-METHOXY-1H-INDOL-3-YL)ETHYLAMINE | MERCK SHARP & DOHME LTD. (GB) | 2001-02-13 | — | — | US | disclosed |