Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | G6PD | P11413 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2418429 | 0.96 | MEN1 (0.46) | MEN1KMT2AMAPTLMNAMAPK1 | |
| SCHEMBL4198065 | 0.92 | MEN1 (0.37) | MEN1KMT2AMAPTLMNAMAPK1 | |
| SCHEMBL2419389 | 0.91 | KMT2A (0.50) | MEN1KMT2AMAPTLMNAMAPK1 | |
| SCHEMBL4970353 | 0.88 | MEN1 (0.39) | MEN1KMT2AMAPTLMNAMAPK1 | |
| SCHEMBL4197299 | 0.88 | MAPK9 (0.47) | MEN1KMT2AMAPTLMNAMAPK1 | |
| SCHEMBL2419313 | 0.87 | MEN1 (0.49) | MEN1KMT2AMAPTLMNAMAPK1 | |
| SCHEMBL2423188 | 0.85 | KMT2A (0.48) | MEN1KMT2AMAPTLMNAMAPK1 | |
| SCHEMBL2428331 | 0.85 | KMT2A (0.51) | MEN1KMT2ALMNAMAPK1SIRT2 | |
| SCHEMBL2423593 | 0.84 | KMT2A (0.48) | MEN1KMT2AMAPTLMNAMAPK1 | |
| SCHEMBL2421018 | 0.84 | ALDH1A1 (0.47) | MEN1KMT2AMAPTLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218374-A1 | PHARMACEUTICALLY ACTIVE SULFONAMIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2002-07-03 | — | — | EP | claimed |
| WO-2001023378-A1 | PHARMACEUTICALLY ACTIVE SULFONAMIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2001-04-05 | — | — | WO | claimed |