Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.71 |
| ▸ | NPC1 | O15118 | 2/20 | 0.61 |
| ▸ | PLK1 | P53350 | 1/20 | 0.61 |
| ▸ | NQO1 | P15559 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.55 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.55 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10733626 | 0.84 | L3MBTL1 (0.64) | PARP10PLK1PLA2G4BL3MBTL1 | |
| SCHEMBL2093915 | 0.84 | TP53 (0.64) | PLA2G4BKMT2AALDH1A1HPGDKDM4E | |
| SCHEMBL1086282 | 0.83 | PARP10 (1.00) | PARP10NPC1PLK1NQO1NPSR1 | |
| SCHEMBL29960960 | 0.83 | PARP10 (1.00) | PARP10NPC1PLK1NQO1NPSR1 | |
| SCHEMBL1367365 | 0.83 | PARP10 (0.70) | PARP10NPC1PLK1NQO1NPSR1 | |
| SCHEMBL845348 | 0.83 | NPSR1 (0.79) | PARP10NPC1PLK1NQO1NPSR1 | |
| Hydrochloric Acid SCHEMBL4381217 | 0.82 | PARP10 (0.96) | PARP10NPC1PLK1NQO1NPSR1 | |
| SCHEMBL22115534 | 0.82 | PARP10 (0.69) | PARP10NPC1PLK1NQO1NPSR1 | |
| Hydrochloric Acid SCHEMBL5494037 | 0.82 | PARP10 (0.96) | PARP10NPC1PLK1NQO1NPSR1 | |
| SCHEMBL3809849 | 0.81 | PARP10 (0.68) | PARP10NPC1PLK1NQO1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0702013-B1 | Imidazopyridines | MERCK PATENT GMBH (DE) | 2001-06-13 | — | — | EP | disclosed |
| US-5684015-A | ANGIOTENSIN ANTAGONIST AS HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-11-04 | — | — | US | disclosed |
| EP-0702013-A2 | Imidazopyridines | MERCK PATENT GmbH (DE) | 1996-03-20 | — | — | EP | disclosed |
| US-5438063-A | Hypotensive agents, cardiac insufficiency, increased intraocular pressure, and CNS disorders | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-08-01 | — | — | US | disclosed |
| EP-0657454-A1 | Imidazopyridazines being angiotensin II antagonists | MERCK PATENT GmbH (DE) | 1995-06-14 | — | — | EP | disclosed |
| US-5389642-A | Exhibit antagonistic properties toward angiotensin(II); useful for treatment of hypertensioni, aldosteronism, cardiac insufficiency, increased intraocular pressure and disorders of the central nervous system | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-02-14 | — | — | US | disclosed |
| EP-0628556-A1 | Imidazopyridines | MERCK PATENT GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |
| EP-0602521-A1 | Imidazopyridines | MERCK PATENT GmbH (DE) | 1994-06-22 | — | — | EP | disclosed |
| US-5242928-A | Angiotensin II antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-09-07 | — | — | US | disclosed |
| EP-0547514-A2 | Imidazopyridine derivatives with angiotensin-II antagonist properties | MERCK PATENT GmbH (DE) | 1993-06-23 | — | — | EP | disclosed |
| US-4479965-A | ANTILIPEMIC, ANTICHOLESTEROL AGENTS | SANKYO COMPANY, LIMITED (JP) | 1984-10-30 | — | — | US | disclosed |
| US-4451481-A | ANTICHOLESTEROL AGENTS | SANKYO COMPANY LIMITED (JP) | 1984-05-29 | — | — | US | disclosed |
| US-4447626-A | TREATMENT OF HYPERCHOLESTEROLEMIA | SANKYO COMPANY LIMITED (JP) | 1984-05-08 | — | — | US | disclosed |
| US-4438277-A | Hydronaphthalene derivatives | SANKYO COMPANY, LIMITED (JP) | 1984-03-20 | — | — | US | disclosed |
| EP-0076601-A1 | Octahydronaphthalene derivatives and their preparation | SANKYO COMPANY LIMITED (JP) | 1983-04-13 | — | — | EP | disclosed |
| EP-0074222-A1 | MB-530B derivatives, their preparation and pharmaceutical compositions containing them | SANKYO COMPANY LIMITED (JP) | 1983-03-16 | — | — | EP | disclosed |
| EP-0070649-A2 | ML-236B Derivatives, a process for their preparation and pharmaceutical compositions containing them | SANKYO COMPANY LIMITED (JP) | 1983-01-26 | — | — | EP | disclosed |
| EP-0065835-A1 | M-4 and iso M-4 derivatives, their preparation and compositions containing them | SANKYO COMPANY LIMITED (JP) | 1982-12-01 | — | — | EP | disclosed |
| EP-0065843-A1 | New M-4 and iso M-4 derivatives, their preparation and compositions containing them | SANKYO COMPANY LIMITED (JP) | 1982-12-01 | — | — | EP | disclosed |
| US-4361515-A | Antihyperlipemic dihydro-ML-236B derivatives, their preparation and use | SANKYO COMPANY, LIMITED (JP) | 1982-11-30 | — | — | US | disclosed |