Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | LTA4H | P09960 | 3/20 | 0.33 |
| ▸ | GHSR | Q92847 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434047 | 0.93 | CYP1A2 (0.36) | CYP1A2CYP2C9CYP2C19HTTSLC7A5 | |
| SCHEMBL7440427 | 0.88 | SMN1; SMN2 (0.44) | CYP1A2CYP2C9CYP2C19HTTLTA4H | |
| SCHEMBL8695584 | 0.86 | KCNA5 (0.36) | SYKMAPTXBP1NPSR1TDP1 | |
| SCHEMBL7438701 | 0.86 | CYP1A2 (0.48) | CYP1A2CYP2C9CYP2C19HTTSLC7A5 | |
| SCHEMBL7436644 | 0.86 | CYP1A2 (0.35) | CYP1A2CYP2C9CYP2C19HTTSLC7A5 | |
| SCHEMBL7439136 | 0.85 | SMN1; SMN2 (0.48) | CYP1A2CYP2C9CYP2C19HTTSLC7A5 | |
| SCHEMBL7431704 | 0.85 | LNPEP (0.35) | SYKMAPTXBP1NPSR1TDP1 | |
| SCHEMBL7431022 | 0.85 | CYP1A2 (0.47) | CYP1A2CYP2C9CYP2C19HTTLTA4H | |
| SCHEMBL7439595 | 0.85 | GHSR (0.36) | HTTSLC7A5SYKLTA4HGHSR | |
| SCHEMBL7439049 | 0.83 | CYP1A2 (0.36) | CYP1A2CYP2C9CYP2C19HTTSLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | disclosed |