Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 9/20 | 0.57 |
| ▸ | F2 | P00734 | 3/20 | 0.57 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.57 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.57 |
| ▸ | TMPRSS6 | Q8IU80 | 3/20 | 0.57 |
| ▸ | ST14 | Q9Y5Y6 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MASP2 | O00187 | 1/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7885601 | 0.81 | ALDH1A1 (0.47) | PRSS1F2PLAU | |
| SCHEMBL7498540 | 0.77 | PRSS1 (0.47) | PRSS1F2PRSS2PRSS3PLAU | |
| SCHEMBL7789704 | 0.76 | MEN1 (0.32) | LMNA | |
| SCHEMBL1446234 | 0.75 | PRSS1 (0.59) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL1086164 | 0.74 | TSHR (0.55) | — | |
| SCHEMBL537030 | 0.74 | LMNA (0.77) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL6289073 | 0.73 | PRSS1 (0.59) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL17570501 | 0.73 | PRSS1 (0.59) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL4553738 | 0.72 | F2 (0.77) | PRSS1F2PRSS2PRSS3TMPRSS6 | |
| SCHEMBL5640360 | 0.72 | MAPT (0.50) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1187186-A | Substituted phenyl amindines, medicaments containing these compounds and process for producing them | THOMAE GMBH DR K (DE) | 1998-07-08 | — | — | CN | disclosed |
| EP-0674623-A1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014776-A2 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-07-07 | — | — | WO | disclosed |