Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 7/20 | 0.51 |
| ▸ | KCNN3 | Q9UGI6 | 9/20 | 0.48 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.48 |
| ▸ | KCNN2 | Q9H2S1 | 2/20 | 0.48 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.48 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.48 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.48 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.48 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.48 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.48 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.48 |
| ▸ | AGTR2 | P50052 | 6/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437203 | 0.93 | KCNN3 (0.47) | AGTR1KCNN3KCNN1KCNN2PRKAB2 | |
| SCHEMBL7442662 | 0.91 | KCNN3 (0.45) | AGTR1KCNN3KCNN1KCNN2PRKAB2 | |
| SCHEMBL7443166 | 0.90 | AGTR1 (0.46) | AGTR1KCNN3KCNN1KCNN2PRKAB2 | |
| SCHEMBL7433929 | 0.90 | AGTR1 (0.46) | AGTR1KCNN3KCNN1KCNN2PRKAB2 | |
| SCHEMBL7442449 | 0.90 | PRKAB2 (0.47) | AGTR1KCNN3KCNN1KCNN2PRKAB2 | |
| SCHEMBL7441328 | 0.90 | KCNN3 (0.62) | AGTR1KCNN3KCNN1KCNN2AGTR2 | |
| SCHEMBL7442072 | 0.89 | AGTR1 (0.47) | AGTR1KCNN3KCNN1KCNN2PRKAB2 | |
| SCHEMBL7437766 | 0.89 | AGTR1 (0.47) | AGTR1KCNN3KCNN1KCNN2PRKAB2 | |
| SCHEMBL7434311 | 0.89 | AGTR1 (0.45) | AGTR1KCNN3KCNN1KCNN2PRKAB2 | |
| SCHEMBL7434247 | 0.89 | AGTR1 (0.46) | AGTR1KCNN3KCNN1KCNN2PRKAB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-7278150-A | — | — | None | — | — | JP | disclosed |
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| JP-H07278150-A | PYRAZOLO(1,5-(SMALL)A)PYRIMIDINE DERIVATIVE | SHIONOGI & CO LTD | 1995-10-24 | — | — | JP | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |