Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPB2 | Q96IY4 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 5/20 | 0.33 |
| ▸ | ACE | P12821 | 3/20 | 0.33 |
| ▸ | ECE1 | P42892 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.31 |
| ▸ | CPA1 | P15085 | 1/20 | 0.30 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7441128 | 1.00 | CPB2 (0.37) | CPB2ALDH1A1MAPTLMNAPTGS2 | |
| SCHEMBL11329932 | 0.79 | CPB2 (0.57) | CPB2ALDH1A1MAPTLMNAPTGS2 | |
| SCHEMBL11325221 | 0.76 | CPB2 (0.59) | CPB2ALDH1A1MAPTLMNAPTGS2 | |
| SCHEMBL7434672 | 0.76 | FOLH1 (0.47) | CPB2ECE1 | |
| SCHEMBL7434561 | 0.76 | TGFBR1 (0.41) | CPB2MME | |
| SCHEMBL7434568 | 0.76 | TGFBR1 (0.41) | CPB2MME | |
| SCHEMBL7434665 | 0.76 | FOLH1 (0.47) | CPB2ECE1 | |
| SCHEMBL220338 | 0.76 | ALDH1A1 (0.41) | ALDH1A1MAPTLMNAPTGS2TDP1 | |
| SCHEMBL220339 | 0.76 | ALDH1A1 (0.41) | ALDH1A1MAPTLMNAPTGS2TDP1 | |
| SCHEMBL7431713 | 0.73 | FOLH1 (0.41) | ALDH1A1MAPTLMNAMMEMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1989012627-A1 | S-NITROSO DERIVATIVES OF ACE INHIBITORS AND THE USE THEREOF | BRIGHAM AND WOMEN'S HOSPITAL (US) | 1989-12-28 | — | — | WO | claimed |
| US-5536723-A | VASODILATORS | BRIGHAM & WOMEN'S HOSPITAL (US) | 1996-07-16 | — | — | US | disclosed |
| US-5356890-A | Angiotensin converting enzyme | BRIGHAM AND WOMEN'S HOSPITAL (US) | 1994-10-18 | — | — | US | disclosed |
| US-5187183-A | Cardiovascular-renal disease; anticoagulants, hypotensive agents; vasodilators; pregnancy toxemia; sclerodema; angiotensin-converting-enzyme inhibitors | BRIGHAM & WOMEN'S HOSPITAL (US) | 1993-02-16 | — | — | US | disclosed |
| US-5025001-A | S-nitroso derivatives of ACE inhibitors and the use thereof | BRIGHAM AND WOMEN'S HOSPITAL (US) | 1991-06-18 | — | — | US | disclosed |
| US-5002964-A | S-nitrosocaptopril compounds and the use thereof | BRIGHAM & WOMEN'S HOSPITAL (US) | 1991-03-26 | — | — | US | disclosed |
| WO-1989012627-A1 | S-NITROSO DERIVATIVES OF ACE INHIBITORS AND THE USE THEREOF | BRIGHAM AND WOMEN'S HOSPITAL (US) | 1989-12-28 | — | — | WO | disclosed |