Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18570070 | 0.79 | KDM4E (0.43) | ALDH1A1POLBGAATSHRKMT2A | |
| SCHEMBL27453949 | 0.75 | DHFR (0.36) | GAATSHRSMN1; SMN2 | |
| SCHEMBL28045734 | 0.75 | KDM4E (0.32) | ALDH1A1GAAKDM4EHPGD | |
| SCHEMBL2148737 | 0.73 | KDM4E (0.39) | ALDH1A1POLBGAATSHRKMT2A | |
| SCHEMBL26534292 | 0.72 | L3MBTL1 (0.39) | ALDH1A1POLBGAATSHRKMT2A | |
| SCHEMBL27467896 | 0.72 | MAPT (0.36) | ALDH1A1GAACRHR1KMT2AKDM4E | |
| SCHEMBL27284949 | 0.70 | GAA (0.39) | ALDH1A1GAAKMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL4374888 | 0.68 | CRHR1 (0.31) | ALDH1A1CRHR1 | |
| SCHEMBL9731091 | 0.68 | ABCB11 (0.37) | ALDH1A1POLBGAATSHRPDK2 | |
| SCHEMBL27289019 | 0.68 | CRHR1 (0.33) | ALDH1A1CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009155448-A1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | LIGAND PHARMACEUTICALS INC. (US) | 2009-12-23 | — | — | WO | disclosed |
| WO-2009155448-A1 | BIPHENYL SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | LIGAND PHARMACEUTICALS INC. (US) | 2009-12-23 | — | — | WO | disclosed |