Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MASP2 | O00187 | 2/20 | 0.47 |
| ▸ | PLAU | P00749 | 2/20 | 0.46 |
| ▸ | KLK8 | O60259 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | F10 | P00742 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PLAT | P00750 | 1/20 | 0.46 |
| ▸ | KLK4 | Q9Y5K2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | CA9 | Q16790 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5845871 | 0.88 | NR4A1 (0.51) | MASP2PLAULMNASMN1; SMN2SLC6A2 | |
| SCHEMBL10942377 | 0.88 | LMNA (0.59) | MASP2PLAULMNASMN1; SMN2SLC6A2 | |
| SCHEMBL7450597 | 0.87 | CTRB1 (0.49) | MASP2PLAUKLK8F2F10 | |
| SCHEMBL8363489 | 0.86 | NPC1 (0.50) | ALDH1A1MASP2LMNASMN1; SMN2SLC6A2 | |
| SCHEMBL6655085 | 0.86 | PLAU (0.49) | MASP2PLAUKLK8F2F10 | |
| Ammonia Solution, Strong SCHEMBL6511018 | 0.85 | LMNA (0.46) | ALDH1A1MASP2PLAUKLK8F2 | |
| SCHEMBL8407251 | 0.84 | SRD5A2 (0.48) | MASP2LMNASMN1; SMN2SLC6A2SLC6A3 | |
| SCHEMBL2771354 | 0.84 | ENPP2 (0.52) | ALDH1A1MASP2PLAUF2PLG | |
| SCHEMBL28842161 | 0.84 | PLAU (0.50) | MASP2PLAUKLK8F2F10 | |
| SCHEMBL7276193 | 0.84 | LMNA (0.55) | MASP2LMNASMN1; SMN2SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403578-B1 | ANTICOAGULANTS, CARDIOVASCULAR DISORDERS | SMITHKLINE BEECHAM CORPORATION | 2002-06-11 | — | — | US | disclosed |
| EP-0674623-A1 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-10-04 | — | — | EP | disclosed |
| WO-1994014776-A2 | BICYCLIC FIBRINOGEN ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-07-07 | — | — | WO | disclosed |