Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.39 |
| ▸ | GBA1 | P04062 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7443310 | 0.92 | POLB (0.36) | POLBGBA1TP53MAPTALDH1A1 | |
| SCHEMBL7442097 | 0.88 | ATM (0.37) | GBA1TP53MAPTALDH1A1LMNA | |
| SCHEMBL6174613 | 0.87 | CYP2C9 (0.44) | CYP2C9ALDH1A1 | |
| SCHEMBL7444008 | 0.86 | MAPT (0.37) | TP53MAPTALDH1A1 | |
| SCHEMBL7444945 | 0.86 | TBXAS1 (0.42) | TBXAS1ALDH1A1 | |
| SCHEMBL7450465 | 0.86 | ATIC (0.38) | — | |
| SCHEMBL7445975 | 0.85 | POLB (0.38) | POLBGBA1CYP2C9ALDH1A1LMNA | |
| Pyridine SCHEMBL7444959 | 0.85 | TBXAS1 (0.36) | POLBTBXAS1TP53ALDH1A1 | |
| SCHEMBL7444223 | 0.85 | ALDH1A1 (0.37) | POLBMAPTALDH1A1LMNA | |
| SCHEMBL7444228 | 0.85 | ALDH1A1 (0.37) | POLBMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0668860-B1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | UPJOHN CO (US) | 2002-09-11 | — | — | EP | claimed |
| EP-0668860-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | PHARMACIA & UPJOHN COMPANY (US) | 1995-08-30 | — | — | EP | claimed |
| WO-1994011361-A1 | PYRAN-2-ONES AND 5,6-DIHYDROPYRAN-2-ONES USEFUL FOR TREATING HIV AND OTHER RETROVIRUSES | THE UPJOHN COMPANY (US) | 1994-05-26 | — | — | WO | claimed |
| EP-1203770-A1 | Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hyperplasia and other diseases | PHARMACIA & UPJOHN COMPANY (US) | 2002-05-08 | — | — | EP | disclosed |