SCHEMBL7442764

SCHEMBL7442764

NCC1=CC(c2ccccc2)Cc2c1ccc(OC(=O)Nc1ccccc1)c2OC(=O)Nc1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
GAA P10253 5/20 0.39
ALDH1A1 P00352 3/20 0.39
HSP90AA1 P07900 1/20 0.35
KDM4E B2RXH2 2/20 0.35
BLM P54132 1/20 0.35
KMT2A Q03164 1/20 0.35
PTGS1 P23219 1/20 0.34
PTGS2 P35354 1/20 0.34
RAB9A P51151 2/20 0.33
MAPT P10636 2/20 0.33
NPC1 O15118 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7439893 0.82
Hydrochloric Acid SCHEMBL7310685 0.74 ACHE (0.42) GAAALDH1A1KDM4EPTGS2RAB9A
SCHEMBL9802336 0.73 KDM4E (0.43) GAAALDH1A1HSP90AA1KDM4EBLM
Hydrochloric Acid SCHEMBL9802239 0.70 MAPT (0.38) GAAALDH1A1KDM4EKMT2ARAB9A
Hydrochloric Acid SCHEMBL7447474 0.70 DRD2 (0.35) GAAALDH1A1KDM4EKMT2ARAB9A
SCHEMBL7444849 0.70 CARM1 (0.36) GAAKDM4E
SCHEMBL7444847 0.70 CARM1 (0.36) GAAKDM4E
Hydrochloric Acid SCHEMBL7307954 0.68 DRD1 (0.42) KDM4EMAPT
SCHEMBL7548189 0.68 NPC1 (0.38) GAAALDH1A1KDM4ERAB9ANPC1
SCHEMBL1835068 0.61 GAA (0.56) GAAALDH1A1HSP90AA1KDM4EBLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5621133-A PREPARING A 1-(3,4-DIALKOXYPHENYL),3-HYDROXYALKANE(C6-C12) BY EPOXIDIZING A HALO DERIVATIVE WITH A BASE FOLLOWED BY DECYCLICIZING WITH AN ORGANOMETALLIC COMPOUND IN A SOLVENT; NAPHTHYLENES, ISOCHROMENES AND ISOTHIOCHROMENES DENINNO MICHAEL P (US) 1997-04-15 US disclosed
US-5591884-A PROTECTED HYDROXYALKYLCATECHOL INTERMEDIATES ABBOTT LABORATORIES (US) 1997-01-07 US disclosed
WO-1996038435-A1 DOPAMINE AGONISTS ABBOTT LABORATORIES (US) 1996-12-05 WO disclosed