Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ARG1 | P05089 | 2/20 | 0.31 |
| ▸ | ARG2 | P78540 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26667126 | 0.83 | CYP2C19 (0.61) | CYP2C19KDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL26667139 | 0.81 | CYP2C19 (0.59) | CYP2C19KDM4EKMT2A | |
| SCHEMBL27585847 | 0.80 | CYP2C19 (0.64) | CYP2C19 | |
| SCHEMBL7370249 | 0.78 | KDM4E (0.36) | CYP2C19KDM4EKMT2AARG1ARG2 | |
| SCHEMBL8914159 | 0.78 | CYP2C19 (0.68) | CYP2C19 | |
| SCHEMBL3092703 | 0.76 | CYP2C19 (0.39) | CYP2C19KDM4EKMT2A | |
| SCHEMBL4294182 | 0.76 | CYP2C19 (0.37) | CYP2C19KDM4EKMT2AARG1ARG2 | |
| SCHEMBL27522485 | 0.74 | CYP2C19 (0.35) | CYP2C19KDM4EKMT2A | |
| SCHEMBL15774458 | 0.74 | KDM4E (0.41) | KDM4EKMT2A | |
| SCHEMBL855051 | 0.74 | OPRM1 (0.38) | CYP2C19KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073633-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 2001-02-07 | — | — | EP | claimed |
| WO-1999057098-A2 | SUBSTITUTED BETA-AMINO ACID INHIBITORS OF METHIONINE AMINOPEPTIDASE-2 | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | claimed |