Orcinol

Orcinol

SCHEMBL7442805

Cc1cc(O)cc(O)c1.O=S(=O)(O)c1cccc(Cl)c1Cl

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
PTGES2 Q9H7Z7 5/20 0.43
MCOLN3 Q8TDD5 1/20 0.41
TSHR P16473 2/20 0.40
F2 P00734 3/20 0.39
LMNA P02545 1/20 0.37
KMT2A Q03164 1/20 0.37
ALDH1A1 P00352 2/20 0.36
ACHE P22303 1/20 0.36
HSD17B1 P14061 1/20 0.36
HSD17B2 P37059 1/20 0.36
BRD4 O60885 1/20 0.36
AKR1B1 P15121 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL562742 0.83 TSHR (0.52) PTGES2MCOLN3TSHRLMNAKMT2A
Hydrochloric Acid SCHEMBL942823 0.81 TSHR (0.50) PTGES2MCOLN3TSHRLMNAKMT2A
SCHEMBL13278151 0.81 TSHR (0.50) PTGES2MCOLN3TSHRLMNAKMT2A
SCHEMBL5674206 0.80 F2 (0.60) F2KMT2A
Orcinol SCHEMBL7441405 0.74 PGR (0.49) TSHRKMT2AALDH1A1AKR1B1
SCHEMBL974591 0.72 HSD11B1 (0.49) ALDH1A1
SCHEMBL4313799 0.72 MYC (0.43) MCOLN3TSHRLMNAKMT2AALDH1A1
Orcinol SCHEMBL1046168 0.71 ALDH1A1 (0.63) TSHRLMNAKMT2AALDH1A1ACHE
Hydrochloric Acid SCHEMBL11155347 0.71 HSD11B1 (0.47) ALDH1A1
Hydrochloric Acid SCHEMBL28288401 0.71 MYC (0.42) MCOLN3TSHRLMNAKMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0859607-B1 GUANIDINO PROTEASE INHIBITORS DIMENSIONAL PHARM INC (US) 2002-12-18 EP disclosed
EP-0859607-A4 GUANIDINO PROTEASE INHIBITORS DIMENSIONAL PHARM INC (US) 1999-05-06 EP disclosed
EP-0859607-A1 GUANIDINO PROTEASE INHIBITORS 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 1998-08-26 EP disclosed
US-5792769-A POTENT ANTICOAGULANT, ANTIINFLAMMATORY AGENT; TREATMENT/PROPHYLAXIS OF RESPIRATORY SYSTEM DISORDERS, VASCULAR SYSTEM DISORDERS, ANTITUMOR AGENTS 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 1998-08-11 US disclosed
WO-1997011693-A1 GUANIDINO PROTEASE INHIBITORS 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) 1997-04-03 WO disclosed