Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12390669 | 0.68 | IDO1 (0.41) | SMN1; SMN2ALDH1A1IDO1KDM4EGRIN2D | |
| SCHEMBL7816527 | 0.68 | GAA (0.41) | SMN1; SMN2ALDH1A1LMNACYP2C19TSHR | |
| SCHEMBL6513260 | 0.67 | KDM4E (0.49) | ALOX15NFKB1BLMSMN1; SMN2ALDH1A1 | |
| SCHEMBL1259832 | 0.67 | HSD17B10 (0.47) | ALOX15NFKB1BLMSMN1; SMN2ALDH1A1 | |
| Chelidamic Acid SCHEMBL742928 | 0.66 | ALOX15 (1.00) | ALOX15NFKB1BLMSMN1; SMN2ALDH1A1 | |
| SCHEMBL7830760 | 0.64 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1IDO1KDM4EHPGD | |
| Chelidamic Acid SCHEMBL9658074 | 0.64 | ALOX15 (0.95) | ALOX15NFKB1BLMSMN1; SMN2ALDH1A1 | |
| Chelidamic Acid SCHEMBL1176783 | 0.64 | ALOX15 (0.95) | ALOX15NFKB1BLMSMN1; SMN2ALDH1A1 | |
| SCHEMBL1006834 | 0.64 | ALOX15 (0.48) | ALOX15NFKB1BLMSMN1; SMN2ALDH1A1 | |
| SCHEMBL27960983 | 0.64 | KDM4E (0.37) | ALDH1A1CYP2C19IDO1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706525-A1 | ANTIHYPERTENSIVE TRICYCLIC AZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | Novartis AG (CH) | 1996-04-17 | — | — | EP | disclosed |
| WO-1995001353-A1 | ANTIHYPERTENSIVE TRICYCLIC AZEPINE DERIVATIVES USEFUL AS INHIBITORS OF ENKEPHALINASE AND ACE | CIBA-GEIGY AG (CH) | 1995-01-12 | — | — | WO | disclosed |