Chelidamic Acid

Chelidamic Acid

SCHEMBL1176783

O.O=C(O)c1cc(=O)cc(C(=O)O)[nH]1

nearest known ligand 0.95

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Chelidamic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 2/20 0.44
GRIN2A known ✓ Q12879 2/20 0.44
ALOX15 P16050 2/20 0.95
BLM P54132 2/20 0.95
NFKB1 P19838 1/20 0.95
SMN1; SMN2 Q16637 1/20 0.95
ALDH1A1 P00352 2/20 0.54
LMNA P02545 1/20 0.54
CYP2C19 P33261 3/20 0.50
TSHR P16473 2/20 0.47
GPR35 Q9HC97 3/20 0.44
HPGD P15428 3/20 0.44
KDM4E B2RXH2 2/20 0.44
HSD17B10 Q99714 2/20 0.44
GRIN2D O15399 2/20 0.44
GRIN3B O60391 2/20 0.44
CYP1A2 P05177 2/20 0.44
KMT2A Q03164 2/20 0.44
GRIN1 Q05586 2/20 0.44
GRIN2B Q13224 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Chelidamic Acid SCHEMBL742928 0.97 ALOX15 (1.00) ALOX15BLMNFKB1SMN1; SMN2ALDH1A1
Chelidamic Acid SCHEMBL9658074 0.95 ALOX15 (0.95) ALOX15BLMNFKB1SMN1; SMN2ALDH1A1
SCHEMBL14634236 0.83 ALOX15 (0.72) ALOX15BLMNFKB1SMN1; SMN2ALDH1A1
SCHEMBL13075694 0.78 ALOX15 (0.65) ALOX15BLMNFKB1SMN1; SMN2ALDH1A1
Chelidamic Acid SCHEMBL1535360 0.75 ALOX15 (0.60) ALOX15BLMNFKB1SMN1; SMN2ALDH1A1
SCHEMBL4264907 0.75 ALOX15 (0.61) ALOX15BLMNFKB1SMN1; SMN2ALDH1A1
SCHEMBL13872418 0.74 SMN1; SMN2 (0.61) ALOX15BLMNFKB1SMN1; SMN2ALDH1A1
Orotic Acid SCHEMBL16916880 0.73 ALDH1A1 (0.95) ALOX15BLMNFKB1SMN1; SMN2ALDH1A1
Orotic Acid SCHEMBL29592552 0.73 ALDH1A1 (0.95) ALOX15BLMNFKB1SMN1; SMN2ALDH1A1
Orotic Acid SCHEMBL119625 0.73 ALDH1A1 (0.95) ALOX15BLMNFKB1SMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 137 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5683793-A Ink jet transparencies XEROX CORPORATION (US) 1997-11-04 US claimed
US-5589277-A INK JET PRINTING, AQUEOUS INKS, FAST DRYING XEROX CORPORATION (US) 1996-12-31 US claimed
EP-0667246-A1 Recording sheets containing amino acids, hydroxy acids, and polycarboxyl compounds XEROX CORPORATION (US) 1995-08-16 EP claimed
US-20250214985-A1 MACROCYCLIC COMPLEXES OF ALPHA-EMITTING RADIONUCLIDES AND THEIR USE IN TARGETED RADIOTHERAPY OF CANCER CORNELL UNIVERSITY (US) 2025-07-03 US disclosed
US-20250163040-A1 MACROCYCLIC COMPLEXES OF ALPHA-EMITTING RADIONUCLIDES AND THEIR USE IN TARGETED RADIOTHERAPY OF CANCER CORNELL UNIVERSITY (US) 2025-05-22 US disclosed
US-12258339-B2 Macrocyclic complexes of alpha-emitting radionuclides and their use in targeted radiotherapy of cancer CORNELL UNIVERSITY (US) 2025-03-25 US disclosed
EP-4458418-A2 MACROCYCLIC COMPLEXES OF ALPHA-EMITTING RADIONUCLIDES AND THEIR USE IN TARGETED RADIOTHERAPY OF CANCER Cornell University (US) 2024-11-06 EP disclosed
US-12103922-B2 Macrocyclic complexes of alpha-emitting radionuclides and their use in targeted radiotherapy of cancer CORNELL UNIVERSITY (US) 2024-10-01 US disclosed
EP-3600452-B1 MACROCYCLIC COMPLEXES OF ALPHA-EMITTING RADIONUCLIDES AND THEIR USE IN TARGETED RADIOTHERAPY OF CANCER UNIV CORNELL (US) 2024-09-04 EP disclosed
US-20240254085-A1 CHELATORS FOR RADIOMETALS AND METHODS OF MAKING AND USING SAME THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2024-08-01 US disclosed
US-RE49918-E1 Cytotoxic benzodiazepine derivatives IMMUNOGEN, INC. (US) 2024-04-16 US disclosed
WO-2001017999-A2 AMINO-TRIAZOLOPYRIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2001-03-15 WO disclosed
WO-2000050470-A2 CATALYSTS CONTAINING N-PYRROLYL SUBSTITUTED NITROGEN DONORS EASTMAN CHEMICAL COMPANY (US) 2000-08-31 WO disclosed
US-5757408-A PRINTING IMAGE ON SUBSTRATE COATED WITH AMINO-ACID DERIVATIVE ADDITIVE; QUICK DRYING OF INK, OPTICAL DENSITY, NONCURLING XEROX CORPORATION (US) 1998-05-26 US disclosed
US-5683793-A Ink jet transparencies XEROX CORPORATION (US) 1997-11-04 US disclosed
US-5589277-A INK JET PRINTING, AQUEOUS INKS, FAST DRYING XEROX CORPORATION (US) 1996-12-31 US disclosed
EP-0667246-A1 Recording sheets containing amino acids, hydroxy acids, and polycarboxyl compounds XEROX CORPORATION (US) 1995-08-16 EP disclosed
EP-0046653-B1 METHOD FOR CONVERTING CARBOXYLIC ACID GROUPS TO TRICHLOROMETHYL GROUPS THE DOW CHEMICAL COMPANY (US) 1984-05-16 EP disclosed
US-4419514-A Method for converting carboxylic acid groups to trichloromethyl groups THE DOW CHEMICAL COMPANY (US) 1983-12-06 US disclosed
EP-0046653-A1 Method for converting carboxylic acid groups to trichloromethyl groups THE DOW CHEMICAL COMPANY (US) 1982-03-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250163040-A1 MACROCYCLIC COMPLEXES OF ALPHA-EMITTING RADIONUCLIDES AND THEIR USE IN TARGETED RADIOTHERAPY OF CANCER PSMA1, FOLH1, KLK3 MEN1 12/4885GRIN2A 2528/4885ALOX15 4875/4885
US-12258339-B2 Macrocyclic complexes of alpha-emitting radionuclides and their use in targeted radiotherapy of cancer PSMA1, FOLH1, KLK3 MEN1 12/4885GRIN2A 2528/4885ALOX15 4875/4885
US-12103922-B2 Macrocyclic complexes of alpha-emitting radionuclides and their use in targeted radiotherapy of cancer PSMA1, KLK3, FOLH1 MEN1 15/4885GRIN2A 2597/4885ALOX15 4866/4885
US-20250214985-A1 MACROCYCLIC COMPLEXES OF ALPHA-EMITTING RADIONUCLIDES AND THEIR USE IN TARGETED RADIOTHERAPY OF CANCER PSMA1, FOLH1, KLK3 MEN1 12/4885GRIN2A 2528/4885ALOX15 4875/4885
US-20240254085-A1 CHELATORS FOR RADIOMETALS AND METHODS OF MAKING AND USING SAME RXFP3, SLC39A3, NR4A3 MEN1 306/4885GRIN2A 2875/4885ALOX15 4145/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.