Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 2/20 | 0.43 |
| ▸ | FNTB | P49356 | 2/20 | 0.43 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | JAK1 | P23458 | 3/20 | 0.42 |
| ▸ | TYK2 | P29597 | 3/20 | 0.42 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.40 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7448879 | 0.88 | FNTA (0.41) | SMN1; SMN2NPC1RAB9ACYP2C19FNTA | |
| SCHEMBL4676594 | 0.79 | SLC6A4 (0.53) | SMN1; SMN2NPC1RAB9ACYP2C19JAK2 | |
| SCHEMBL4671109 | 0.78 | SMN1; SMN2 (0.44) | SMN1; SMN2NPC1RAB9ACYP2C19FNTA | |
| SCHEMBL2711762 | 0.77 | GRIN2B (0.54) | SMN1; SMN2NPC1RAB9ACYP2C19FNTA | |
| SCHEMBL7450455 | 0.76 | HTR6 (0.40) | — | |
| SCHEMBL2711765 | 0.75 | USP2 (0.54) | SMN1; SMN2NPC1RAB9ACYP2C19FNTA | |
| SCHEMBL3678518 | 0.75 | SMN1; SMN2 (0.60) | SMN1; SMN2NPC1RAB9ACYP2C19FNTA | |
| SCHEMBL4674308 | 0.72 | FNTA (0.41) | SMN1; SMN2NPC1RAB9ACYP2C19FNTA | |
| SCHEMBL19405263 | 0.71 | PDE4B (0.57) | SMN1; SMN2NPC1RAB9ACYP2C19FNTA | |
| SCHEMBL171260 | 0.71 | FNTA (0.55) | SMN1; SMN2NPC1RAB9ACYP2C19FNTA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998032748-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-30 | — | — | WO | disclosed |