SCHEMBL7444284

SCHEMBL7444284

CC(C)NCCOc1cc[c]cc1

nearest known ligand 0.61

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ADRB2 P07550 1/20 0.49
SIGMAR1 Q99720 1/20 0.46
HTR1B P28222 5/20 0.45
KDM4E B2RXH2 2/20 0.43
ALDH1A1 P00352 2/20 0.43
TDP1 Q9NUW8 1/20 0.43
HRH3 Q9Y5N1 3/20 0.43
NR2E1 Q9Y466 1/20 0.41
HTR1D P28221 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7897828 0.81 SIGMAR1 (0.67) ADRB2SIGMAR1HTR1BKDM4EALDH1A1
SCHEMBL7455578 0.80 SIGMAR1 (0.45) ADRB2SIGMAR1HTR1BKDM4EALDH1A1
SCHEMBL13996940 0.79 DRD2 (0.61) ADRB2SIGMAR1KDM4EALDH1A1TDP1
SCHEMBL13996938 0.79 KDM4E (0.56) ADRB2SIGMAR1HTR1BKDM4EALDH1A1
SCHEMBL10995086 0.79 ADRB2 (0.50) ADRB2SIGMAR1HTR1BKDM4EALDH1A1
SCHEMBL4227450 0.79 HTR1B (0.64) HTR1BKDM4EALDH1A1HTR1D
SCHEMBL10816443 0.78 ADRB2 (0.66) ADRB2SIGMAR1HTR1BKDM4EALDH1A1
SCHEMBL10925063 0.78 DRD4 (0.56) ADRB2SIGMAR1HTR1BKDM4EALDH1A1
SCHEMBL15578427 0.78 KMT2A (0.53) ADRB2SIGMAR1HTR1BKDM4EALDH1A1
SCHEMBL10993048 0.78 DRD2 (0.56) ADRB2SIGMAR1HTR1BKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2002541151-A 2002-12-03 JP claimed
EP-1165557-A1 ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS NEUROGEN CORPORATION (US) 2002-01-02 EP claimed
WO-2000059905-A1 ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS NEUROGEN CORPORATION (US) 2000-10-12 WO claimed
EP-1165557-A1 ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS NEUROGEN CORPORATION (US) 2002-01-02 EP disclosed
WO-2000059905-A1 ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS NEUROGEN CORPORATION (US) 2000-10-12 WO disclosed