Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.67 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.67 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.67 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.67 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.67 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.67 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.67 |
| ▸ | KDM4A | O75164 | 1/20 | 0.65 |
| ▸ | KDM5A | P29375 | 1/20 | 0.65 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7448130 | 0.87 | ALOX5 (0.70) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL7358726 | 0.83 | ALOX5 (0.59) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| 5-Phenylvaleric Acid SCHEMBL503601 | 0.83 | MAPT (0.96) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL4203011 | 0.82 | MEN1 (0.66) | HDAC3MAPK1ADRA1AHDAC4SLC6A3 | |
| SCHEMBL2555645 | 0.81 | MAPT (1.00) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL770290 | 0.81 | MAPT (1.00) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL2554345 | 0.81 | MAPT (1.00) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL2553009 | 0.81 | MAPT (1.00) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL5955839 | 0.81 | MAPT (1.00) | MAPTRXFP1HDAC3MAPK1ADRA1A | |
| SCHEMBL1008045 | 0.81 | MAPT (1.00) | MAPTRXFP1HDAC3MAPK1ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4939147-A | Substituted 3,4-dihydroxy phenylethylamino compounds | FISONS PLC. (GB) | 1990-07-03 | — | — | US | disclosed |
| US-4922022-A | Substituted 3,4-dihydroxy phenylethylamino compounds | FISONS PLC (GB) | 1990-05-01 | — | — | US | disclosed |
| EP-0314725-A1 | 2-(3,4-DIHYDROXYPHENYL)ETHYLAMINES, THEIR PREPARATION AND USE AS PHARMACEUTICAL | FISONS plc (GB) | 1989-05-10 | — | — | EP | disclosed |
| WO-1988009326-A1 | 2-(3,4-DIHYDROXYPHENYL)ETHYLAMINES, THEIR PREPARATION AND USE AS PHARMACEUTICAL | FISONS PLC (GB) | 1988-12-01 | — | — | WO | disclosed |
| EP-0292202-A1 | 2-(3,4-Dihydroxyphenyl ethyl amines, their preparation and use as pharmaceutical compounds | FISONS plc (GB) | 1988-11-23 | — | — | EP | disclosed |