Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.71 |
| ▸ | HPGD | P15428 | 4/20 | 0.71 |
| ▸ | NPC1 | O15118 | 4/20 | 0.71 |
| ▸ | RAB9A | P51151 | 4/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.71 |
| ▸ | MMP2 | P08253 | 5/20 | 0.54 |
| ▸ | MMP9 | P14780 | 5/20 | 0.54 |
| ▸ | MMP8 | P22894 | 5/20 | 0.54 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
| ▸ | COMT | P21964 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | FHIT | P49789 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31412081 | 0.89 | KDM4E (0.79) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL11599505 | 0.88 | KDM4E (0.77) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL15249611 | 0.86 | ALDH1A1 (0.67) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL28640195 | 0.85 | KDM4E (0.73) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL7943525 | 0.85 | KDM4E (0.63) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL31533522 | 0.85 | KDM4E (0.72) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL6124304 | 0.84 | NPC1 (0.61) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL1806763 | 0.84 | KDM4E (0.71) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL31679082 | 0.83 | KDM4E (1.00) | KDM4EALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL4714012 | 0.83 | KDM4E (1.00) | KDM4EALDH1A1HPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968191-A1 | PHENYLBENZIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LTD. (GB) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998034923-A1 | PHENYLBENZIMIDAZOLE DERIVATIVES AS LIGANDS FOR GABA RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 1998-08-13 | — | — | WO | disclosed |