Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 2/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5860388 | 0.88 | ALDH1A1 (0.52) | ALDH1A1POLBRECQLRAB9AKMT2A | |
| SCHEMBL7139929 | 0.84 | ALDH1A1 (0.49) | ALDH1A1RECQLMMP8ARRAB9A | |
| SCHEMBL1557729 | 0.84 | ALDH1A1 (0.47) | ALDH1A1POLBRECQLMMP8RAB9A | |
| SCHEMBL11039515 | 0.84 | ALDH1A1 (0.76) | ALDH1A1POLBRECQLARRAB9A | |
| SCHEMBL5861612 | 0.83 | ALDH1A1 (0.50) | ALDH1A1POLBRECQLARRAB9A | |
| SCHEMBL5860161 | 0.82 | POLB (0.49) | ALDH1A1POLBRECQLRAB9ANPC1 | |
| SCHEMBL2429855 | 0.81 | ALDH1A1 (0.44) | ALDH1A1RECQLMMP8RAB9ANPC1 | |
| SCHEMBL1590182 | 0.81 | ALDH1A1 (0.42) | ALDH1A1POLBRECQLMMP8AR | |
| SCHEMBL10694212 | 0.81 | ALDH1A1 (0.56) | ALDH1A1POLBRECQLARKMT2A | |
| SCHEMBL7787265 | 0.80 | ALDH1A1 (0.47) | ALDH1A1POLBRECQLARRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |