Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 5/20 | 0.38 |
| ▸ | CACNB4 | O00305 | 4/20 | 0.38 |
| ▸ | CACNA1A | O00555 | 4/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 4/20 | 0.38 |
| ▸ | CACNG3 | O60359 | 4/20 | 0.38 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.38 |
| ▸ | CACNB3 | P54284 | 4/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 4/20 | 0.38 |
| ▸ | CACNG7 | P62955 | 4/20 | 0.38 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.38 |
| ▸ | CACNB1 | Q02641 | 4/20 | 0.38 |
| ▸ | CACNG1 | Q06432 | 4/20 | 0.38 |
| ▸ | CACNB2 | Q08289 | 4/20 | 0.38 |
| ▸ | CACNA1S | Q13698 | 4/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.38 |
| ▸ | CACNA1E | Q15878 | 4/20 | 0.38 |
| ▸ | CACNA2D4 | Q7Z3S7 | 4/20 | 0.38 |
| ▸ | CACNA2D3 | Q8IZS8 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6964330 | 0.88 | SLK (0.42) | STK10SLKCLK2GSK3AGSK3B | |
| SCHEMBL627191 | 0.78 | RAB9A (0.35) | STK10SLKKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL7293097 | 0.78 | STK10 (0.40) | FYNSTK10SLK | |
| SCHEMBL7297774 | 0.78 | FYN (0.39) | FYNCLK4KDM4EALDH1A1MAPT | |
| SCHEMBL7303932 | 0.74 | ALDH1A1 (0.40) | FYNKDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7303598 | 0.72 | CA12 (0.35) | KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7293888 | 0.72 | CA12 (0.35) | KDM4EALDH1A1MAPTSMN1; SMN2HTT | |
| SCHEMBL7296783 | 0.71 | DDB1 (0.37) | ALDH1A1 | |
| SCHEMBL13430583 | 0.71 | — | — | |
| SCHEMBL7330474 | 0.69 | MAPT (0.33) | KDM4EALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6004965-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0799209-A1 | NOVEL SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-10-08 | — | — | EP | disclosed |
| WO-1996019459-A1 | NOVEL SULFONAMIDES | F. HOFFMANN-LA ROCHE AG (CH) | 1996-06-27 | — | — | WO | disclosed |