Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 6/20 | 0.57 |
| ▸ | FYN | P06241 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 6/20 | 0.53 |
| ▸ | HTR1B | P28222 | 5/20 | 0.53 |
| ▸ | DRD3 | P35462 | 3/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7445238 | 0.92 | HTR1A (0.50) | HTR1DFYNDRD2HTR1BHTR1A | |
| SCHEMBL7438442 | 0.86 | HTR1A (0.46) | HTR1DFYNDRD2HTR1BHTR1A | |
| SCHEMBL7445758 | 0.80 | HTR1D (0.62) | HTR1DFYNHTR1BHTR1A | |
| SCHEMBL7441439 | 0.77 | HTR1D (0.69) | HTR1DDRD2HTR1BHTR1A | |
| SCHEMBL7439655 | 0.76 | HTR1A (0.48) | HTR1DFYNDRD2HTR1BDRD3 | |
| SCHEMBL7435180 | 0.73 | HTR1D (0.62) | HTR1DFYNDRD2HTR1BDRD3 | |
| SCHEMBL10606282 | 0.71 | FYN (1.00) | FYNDRD2DRD3DRD4HTR1A | |
| SCHEMBL7443429 | 0.71 | HTR1D (0.53) | HTR1DFYNHTR1BHTR1ACYP2D6 | |
| Bromide SCHEMBL7198686 | 0.70 | FYN (0.97) | FYNDRD2DRD3DRD4HTR1A | |
| SCHEMBL8486515 | 0.70 | FYN (0.74) | FYNDRD2DRD3DRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |