Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR1D | P28221 | 4/20 | 0.46 |
| ▸ | HTR1B | P28222 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7445238 | 0.83 | HTR1A (0.50) | HTR1AHTR1DHTR1BDRD2FYN | |
| SCHEMBL7204936 | 0.79 | HTR1A (0.75) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL7208781 | 0.79 | HTR1A (0.75) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL8691952 | 0.77 | DRD3 (0.59) | DRD2DRD3FYN | |
| SCHEMBL7445106 | 0.76 | HTR1D (0.57) | HTR1AHTR1DHTR1BDRD2DRD3 | |
| SCHEMBL7438442 | 0.75 | HTR1A (0.46) | HTR1AHTR1DHTR1BDRD2FYN | |
| SCHEMBL8689261 | 0.75 | DRD3 (0.56) | DRD3 | |
| SCHEMBL7443429 | 0.73 | HTR1D (0.53) | HTR1AHTR1DHTR1BFYN | |
| SCHEMBL7439653 | 0.73 | HTR1B (0.46) | HTR1AHTR1DHTR1BDRD3FYN | |
| SCHEMBL7444866 | 0.72 | HTR1A (0.41) | HTR1AHTR1DHTR1BDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0690843-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |