Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 6/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 5/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7445106 | 0.92 | HTR1D (0.57) | HTR1AHTR1DFYNHTR1BDRD2 | |
| SCHEMBL7438442 | 0.91 | HTR1A (0.46) | HTR1AHTR1DFYNHTR1BDRD2 | |
| SCHEMBL7439655 | 0.83 | HTR1A (0.48) | HTR1AHTR1DFYNHTR1BDRD2 | |
| SCHEMBL7443429 | 0.78 | HTR1D (0.53) | HTR1AHTR1DFYNHTR1BALDH1A1 | |
| SCHEMBL7208944 | 0.75 | HTR1A (0.81) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL7444866 | 0.74 | HTR1A (0.41) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL7441439 | 0.73 | HTR1D (0.69) | HTR1AHTR1DHTR1BDRD2 | |
| SCHEMBL7460946 | 0.71 | FYN (0.65) | HTR1AFYNDRD2ALDH1A1CYP2D6 | |
| SCHEMBL7445758 | 0.71 | HTR1D (0.62) | HTR1AHTR1DFYNHTR1B | |
| SCHEMBL7439653 | 0.71 | HTR1B (0.46) | HTR1AHTR1DFYNHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5639778-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | PHARMACIA & UPJOHN COMPANY (US) | 1997-06-17 | — | — | US | disclosed |
| EP-0690843-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1996-01-10 | — | — | EP | disclosed |
| WO-1994021608-A1 | INDOLETETRALINS HAVING DOPAMINERGIC ACTIVITY | THE UPJOHN COMPANY (US) | 1994-09-29 | — | — | WO | disclosed |