Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGAV | P06756 | 20/20 | 0.64 |
| ▸ | ITGB3 | P05106 | 16/20 | 0.64 |
| ▸ | ITGB6 | P18564 | 8/20 | 0.58 |
| ▸ | ITGB8 | P26012 | 8/20 | 0.58 |
| ▸ | ITGB5 | P18084 | 5/20 | 0.58 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433674 | 1.00 | ITGAV (0.64) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL7436966 | 1.00 | ITGAV (0.64) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL7433962 | 0.90 | ITGB3 (0.52) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL27612659 | 0.87 | ITGAV (0.55) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL7439664 | 0.87 | ITGAV (0.82) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL7444473 | 0.87 | ITGAV (0.82) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL7448931 | 0.87 | ITGAV (0.82) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL7434572 | 0.86 | ITGAV (0.63) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL7434305 | 0.86 | ITGAV (0.63) | ITGAVITGB3ITGB6ITGB8ITGB5 | |
| SCHEMBL7434310 | 0.86 | ITGAV (0.63) | ITGAVITGB3ITGB6ITGB8ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1187592-A4 | ALPHA V INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2002-11-06 | — | — | EP | claimed |
| EP-1187592-A2 | ALPHA V INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2002-03-20 | — | — | EP | claimed |
| WO-2000072801-A2 | ALPHA V INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-12-07 | — | — | WO | claimed |
| EP-1187592-A4 | ALPHA V INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2002-11-06 | — | — | EP | disclosed |
| US-6410526-B1 | BONE DISORDERS; RESTENOSIS; VISION DISORDERS; ANTICHOLESTEROL AGENTS; ANTICANCER, ANTITUMOR AGENTS | MERCK & CO., INC. | 2002-06-25 | — | — | US | disclosed |
| EP-1187592-A2 | ALPHA V INTEGRIN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2002-03-20 | — | — | EP | disclosed |
| WO-2000072801-A2 | ALPHA V INTEGRIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 2000-12-07 | — | — | WO | disclosed |