Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.34 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19453382 | 0.70 | KDM4E (0.35) | MERTK | |
| SCHEMBL6042034 | 0.69 | TLR9 (0.44) | TLR9TLR8TLR7SLC18A3 | |
| SCHEMBL7595673 | 0.69 | TLR9 (0.36) | TLR9TLR8TLR7ALK | |
| SCHEMBL11565325 | 0.68 | KDM1A (0.50) | SLC18A3 | |
| SCHEMBL8317532 | 0.68 | KDM1A (0.50) | SLC18A3 | |
| SCHEMBL8471748 | 0.68 | KDM1A (0.50) | SLC18A3 | |
| SCHEMBL407883 | 0.68 | KDM1A (0.50) | SLC18A3 | |
| SCHEMBL8870050 | 0.68 | KDM1A (0.50) | SLC18A3 | |
| SCHEMBL11565322 | 0.68 | KDM1A (0.50) | SLC18A3 | |
| SCHEMBL6041594 | 0.68 | KMT2A (0.36) | SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |