Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7445765 | 0.90 | AGTR1 (0.31) | AGTR1 | |
| SCHEMBL7442467 | 0.90 | TRPA1 (0.30) | — | |
| SCHEMBL7442646 | 0.90 | GSK3B (0.36) | AGTR1AGTR2 | |
| SCHEMBL7439328 | 0.88 | RAB9A (0.38) | AGTR1AGTR2CRHR1 | |
| SCHEMBL7433797 | 0.88 | — | — | |
| SCHEMBL7438693 | 0.88 | AGTR1 (0.35) | AGTR1AGTR2CRHR1 | |
| SCHEMBL7427170 | 0.87 | CSNK2A1 (0.35) | — | |
| SCHEMBL7434976 | 0.87 | AGTR1 (0.34) | AGTR1AGTR2 | |
| SCHEMBL7440098 | 0.87 | AGTR1 (0.32) | AGTR1AGTR2 | |
| SCHEMBL7447253 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |