Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 11/20 | 0.35 |
| ▸ | MMP1 | P03956 | 10/20 | 0.35 |
| ▸ | MMP3 | P08254 | 9/20 | 0.35 |
| ▸ | MMP7 | P09237 | 8/20 | 0.35 |
| ▸ | MMP9 | P14780 | 8/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4671736 | 1.00 | MMP13 (0.35) | MMP13MMP1MMP3MMP7MMP9 | |
| SCHEMBL4674797 | 0.88 | MMP1 (0.35) | MMP13MMP1MMP3MMP7MMP9 | |
| SCHEMBL7464250 | 0.87 | IRAK4 (0.32) | IRAK4 | |
| SCHEMBL4670750 | 0.86 | IKBKB (0.36) | MMP13MMP1MMP3MMP7MMP9 | |
| SCHEMBL7507631 | 0.86 | IKBKB (0.36) | MMP13MMP1MMP3MMP7MMP9 | |
| SCHEMBL4670933 | 0.84 | MMP1 (0.45) | MMP13MMP1MMP3MMP7MMP9 | |
| SCHEMBL7511113 | 0.84 | MMP1 (0.45) | MMP13MMP1MMP3MMP7MMP9 | |
| SCHEMBL4671384 | 0.81 | HSD11B1 (0.47) | — | |
| SCHEMBL4673266 | 0.78 | USP5 (0.41) | MMP13MMP1MMP3MMP7MMP9 | |
| SCHEMBL4670823 | 0.77 | IRAK4 (0.41) | IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-24 | — | — | EP | claimed |
| WO-1998032748-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-30 | — | — | WO | claimed |
| EP-0958287-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998032748-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-30 | — | — | WO | disclosed |