SCHEMBL744545

SCHEMBL744545

c1ccc(C2C3CNCC32)cc1

nearest known ligand 0.61

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
BPTF Q12830 1/20 0.43
SLC18A3 Q16572 1/20 0.43
SIGMAR1 Q99720 1/20 0.43
KDM1A O60341 2/20 0.42
MAOA P21397 1/20 0.42
CYP11B2 P19099 1/20 0.39
MEN1 O00255 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
KMT2A Q03164 1/20 0.39
CHRNB4 P30926 1/20 0.39
CHRNA3 P32297 1/20 0.39
SSTR4 P31391 1/20 0.39
MAOB P27338 1/20 0.39
KCNH2 Q12809 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6925312 1.00 BPTF (0.43) BPTFSLC18A3SIGMAR1KDM1AMAOA
SCHEMBL7076302 0.95 CYP11B2 (0.44) BPTFSLC18A3SIGMAR1KDM1AMAOA
SCHEMBL19122346 0.85 SLC18A3 (0.50) SLC18A3SIGMAR1KDM1AMAOAMAOB
SCHEMBL16422679 0.76 HTR2C (0.41) KDM1ACHRNB4CHRNA3
SCHEMBL233570 0.74 SLC18A3 (0.58) BPTFSLC18A3SIGMAR1KDM1AMAOA
SCHEMBL8660684 0.74 MAOA (0.55) SLC18A3SIGMAR1KDM1AMAOAMEN1
SCHEMBL3870080 0.74 MAOA (0.55) SLC18A3SIGMAR1KDM1AMAOAMEN1
SCHEMBL3870077 0.74 MAOA (0.55) SLC18A3SIGMAR1KDM1AMAOAMEN1
SCHEMBL10153406 0.73 BPTF (0.42) BPTFSLC18A3SIGMAR1KDM1AMAOA
Hydrochloric Acid SCHEMBL557175 0.72 SLC18A3 (0.56) BPTFSLC18A3SIGMAR1KDM1AMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250115583-A1 BICYCLIC INDAZOLE GLUCOCORTICOID RECEPTOR ANTAGONISTS CORCEPT THERAPEUTICS INCORPORATED 2025-04-10 US disclosed
US-12098141-B2 Bicyclic indazole glucocorticoid receptor antagonists CORCEPT THERAPEUTICS INCORPORATED (US) 2024-09-24 US disclosed
US-20230242514-A1 BICYCLIC INDAZOLE GLUCOCORTICOID RECEPTOR ANTAGONISTS CORCEPT THERAPEUTICS INCORPORATED 2023-08-03 US disclosed
US-11369606-B2 Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use JANSSEN PHARMACEUTICA NV (BE) 2022-06-28 US disclosed
US-20220047593-A1 COMBINATIONS COMPRISING POSITIVE ALLOSTERIC MODULATORS OR ORTHOSTERIC AGONISTS OF METABOTROPIC GLUTAMATERGIC RECEPTOR SUBTYPE 2 AND THEIR USE JANSSEN PHARMACEUTICA NV (BE) 2022-02-17 US disclosed
US-20200138813-A1 COMBINATIONS COMPRISING POSITIVE ALLOSTERIC MODULATORS OR ORTHOSTERIC AGONISTS OF METABOTROPIC GLUTAMATERGIC RECEPTOR SUBTYPE 2 AND THEIR USE JANSSEN PHARMACEUTICA NV (BE) 2020-05-07 US disclosed
US-20200138814-A1 COMBINATIONS COMPRISING POSITIVE ALLOSTERIC MODULATORS OR ORTHOSTERIC AGONISTS OF METABOTROPIC GLUTAMATERGIC RECEPTOR SUBTYPE 2 AND THEIR USE JANSSEN PHARMACEUTICA NV (BE) 2020-05-07 US disclosed
EP-2344470-B1 3-AZABICYCLO[3.1.0]HEXYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS JANSSEN PHARMACEUTICALS INC (US) 2013-11-06 EP disclosed
EP-2430022-A1 1,2,3-TRIAZOLO Ý4,3-A¨PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS Janssen Pharmaceuticals, Inc. (US) 2012-03-21 EP disclosed
US-20110306642-A1 3-AZABICYCLO[3.1.0]HEXYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS ADDEX PHARMA S.A. (CH) 2011-12-15 US disclosed
EP-2344470-A1 3-AZABICYCLO[3.1.0]HEXYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS Ortho-McNeil-Janssen Pharmaceuticals, Inc. (US) 2011-07-20 EP disclosed
WO-2010130424-A9 1,2,4-TRIAZOLO [4,3-A] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) 2011-01-27 WO disclosed
WO-2010130424-A1 1,2,3-TRIAZOLO [4,3-A] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) 2010-11-18 WO disclosed
WO-2010025890-A1 3-AZABICYCLO[3.1.0]HEXYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) 2010-03-11 WO disclosed
US-6096755-A N-substituted azabicycloalkane derivatives, their preparation and use BASF AKTIENGESELLSCHAFT (DE) 2000-08-01 US disclosed
EP-0731802-A1 N-SUBSTITUTED AZABICYCLOALKANE DERIVATIVES AS NEUROLEPTIKA ASF BASF AKTIENGESELLSCHAFT (DE) 1996-09-18 EP disclosed
EP-0728136-A1 N-SUBSTITUTED AZABICYCLOALKANE DERIVATIVES, THEIR PREPARATION AND USE BASF AKTIENGESELLSCHAFT (DE) 1996-08-28 EP disclosed
WO-1995015327-A1 N-SUBSTITUTED AZABICYCLOALKANE DERIVATIVES AS NEUROLEPTIKA ASF BASF AKTIENGESELLSCHAFT (DE) 1995-06-08 WO disclosed
WO-1995013279-A1 N-SUBSTITUTED AZABICYCLOALKANE DERIVATIVES, THEIR PREPARATION AND USE BASF AKTIENGESELLSCHAFT (DE) 1995-05-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110306642-A1 3-AZABICYCLO[3.1.0]HEXYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS GRM2, GRM1, GRIN2C BPTF 3509/4885SLC18A3 545/4885SIGMAR1 687/4885
US-20250115583-A1 BICYCLIC INDAZOLE GLUCOCORTICOID RECEPTOR ANTAGONISTS NR3C1, NR3C2, NR1I2 BPTF 2674/4885SLC18A3 2156/4885SIGMAR1 394/4885
US-20220047593-A1 COMBINATIONS COMPRISING POSITIVE ALLOSTERIC MODULATORS OR ORTHOSTERIC AGONISTS OF METABOTROPIC GLUTAMATERGIC RECEPTOR SUBTYPE 2 AND THEIR USE GRM2, GRIN2A, GRIK2 BPTF 2044/4885SLC18A3 90/4885SIGMAR1 131/4885
US-12098141-B2 Bicyclic indazole glucocorticoid receptor antagonists NR3C1, NR3C2, NR1I2 BPTF 2674/4885SLC18A3 2156/4885SIGMAR1 394/4885
US-20230242514-A1 BICYCLIC INDAZOLE GLUCOCORTICOID RECEPTOR ANTAGONISTS NR3C1, NR3C2, NR1I2 BPTF 2674/4885SLC18A3 2156/4885SIGMAR1 394/4885
US-20200138813-A1 COMBINATIONS COMPRISING POSITIVE ALLOSTERIC MODULATORS OR ORTHOSTERIC AGONISTS OF METABOTROPIC GLUTAMATERGIC RECEPTOR SUBTYPE 2 AND THEIR USE GRM2, GRIN2A, GRIK2 BPTF 2044/4885SLC18A3 90/4885SIGMAR1 131/4885
US-11369606-B2 Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use GRM2, GRIN2A, GRIK2 BPTF 2044/4885SLC18A3 90/4885SIGMAR1 131/4885
US-20200138814-A1 COMBINATIONS COMPRISING POSITIVE ALLOSTERIC MODULATORS OR ORTHOSTERIC AGONISTS OF METABOTROPIC GLUTAMATERGIC RECEPTOR SUBTYPE 2 AND THEIR USE GRM2, GRIN2A, GRIK2 BPTF 2044/4885SLC18A3 90/4885SIGMAR1 131/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.