Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPY2R | P49146 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434962 | 0.99 | ALDH1A1 (0.57) | ALDH1A1MEN1KMT2AAOC3CYP19A1 | |
| SCHEMBL7440554 | 0.92 | MEN1 (0.65) | ALDH1A1MEN1KMT2ACYP19A1 | |
| Hydrochloric Acid SCHEMBL7428326 | 0.91 | MEN1 (0.67) | ALDH1A1MEN1KMT2ACYP19A1 | |
| SCHEMBL7435177 | 0.81 | SLC6A4 (0.40) | ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL7439525 | 0.80 | SMN1; SMN2 (0.57) | ALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7432963 | 0.79 | SMN1; SMN2 (0.41) | ALDH1A1MEN1KMT2ASMN1; SMN2GAA | |
| Hydrochloric Acid SCHEMBL7432896 | 0.79 | SMN1; SMN2 (0.60) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL7435279 | 0.79 | MEN1 (0.62) | ALDH1A1MEN1KMT2ACYP19A1 | |
| SCHEMBL7430973 | 0.79 | KMT2A (0.50) | ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL7436806 | 0.78 | KMT2A (0.52) | ALDH1A1MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4945097-A | THERAPY FOR ANOXIA, HYPOXIA, OR ISCHEMIA | G. D. SEARLE & CO. (US) | 1990-07-31 | — | — | US | disclosed |