Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NCEH1 | Q6PIU2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 5/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | GAK | O14976 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.39 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7340884 | 0.89 | HPGD (0.53) | PLAUMAPTUSP2HPGDMEN1 | |
| SCHEMBL7345019 | 0.88 | PLAU (0.46) | PLAUL3MBTL1NCEH1MAPTUSP2 | |
| SCHEMBL7337530 | 0.79 | AR (0.46) | NCEH1MAPTPDE5AGAKRIPK2 | |
| SCHEMBL7351841 | 0.77 | MYB (0.45) | PLAUMAPTHPGDTP53HSD17B10 | |
| Hydrochloric Acid SCHEMBL7343861 | 0.76 | PLAU (0.59) | PLAUL3MBTL1MAPK1NCEH1MAPT | |
| SCHEMBL2327275 | 0.76 | MRGPRX4 (0.53) | NPC1TP53RAB9AHSD17B10MEN1 | |
| SCHEMBL16741023 | 0.75 | LMNA (0.59) | L3MBTL1MAPTMEN1ALDH1A1GAA | |
| SCHEMBL31433068 | 0.74 | GAA (0.49) | MAPTUSP2HPGDNPC1TP53 | |
| SCHEMBL2855163 | 0.74 | MEN1 (0.49) | L3MBTL1MAPK1MAPTUSP2HPGD | |
| SCHEMBL7720296 | 0.73 | CA9 (0.46) | MAPK1NCEH1MAPTUSP2PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000018-A2 | UROKINASE INHIBITORS | Abbott Laboratories (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999005096-A2 | UROKINASE INHIBITORS | ABBOTT LABORATORIES (US) | 1999-02-04 | — | — | WO | disclosed |