Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433180 | 0.89 | CYP2C19 (0.36) | POLBTDP1CYP2C19CYP4F2CYP4A11 | |
| SCHEMBL28718243 | 0.82 | CYP4F2 (0.38) | POLBCYP4F2CYP4A11MAPTALDH1A1 | |
| SCHEMBL1361079 | 0.82 | CYP2C19 (0.39) | POLBTDP1CYP2C19MAPTALDH1A1 | |
| SCHEMBL17617116 | 0.82 | CYP4F2 (0.42) | POLBCYP4F2CYP4A11MAPTALDH1A1 | |
| SCHEMBL18597562 | 0.81 | CYP4F2 (0.39) | POLBCYP4F2CYP4A11ALDH1A1LMNA | |
| SCHEMBL5879371 | 0.81 | ZDHHC20 (0.40) | POLBCYP2C19CYP4F2CYP4A11MAPT | |
| SCHEMBL354285 | 0.79 | CYP2C19 (0.37) | POLBTDP1CYP2C19MAPTALDH1A1 | |
| SCHEMBL9141375 | 0.78 | DGAT1 (0.36) | CYP4F2CYP4A11MAPTALDH1A1LMNA | |
| SCHEMBL28248731 | 0.78 | CYP2C19 (0.38) | POLBTDP1CYP2C19MAPTALDH1A1 | |
| SCHEMBL16453917 | 0.77 | KDM4E (0.34) | CYP4F2CYP4A11MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776959-A | Anticonvulsant and anxiolytic lactam and thiolactam derivatives | WASHINGTON UNIVERSITY (US) | 1998-07-07 | — | — | US | disclosed |