SCHEMBL7445939

SCHEMBL7445939

CC(=O)N(C[C@H](NC(=O)OCc1ccccc1)C(=O)O)N1C(=O)N[C@H](Cc2ccc(C=NN)cc2)C1=O

nearest known ligand 0.45

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 13/20 0.45
ITGAV P06756 9/20 0.45
ITGA2B P08514 9/20 0.45
IDO1 P14902 2/20 0.40
TDO2 P48775 1/20 0.40
CTSL P07711 5/20 0.37
CTSS P25774 4/20 0.37
CTSK P43235 4/20 0.37
CTSB P07858 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7449328 0.92 ITGB3 (0.40) ITGB3ITGAVITGA2BIDO1TDO2
SCHEMBL7980895 0.86 PLG (0.45) ITGB3ITGAVITGA2BIDO1TDO2
SCHEMBL7980904 0.80 ITGB3 (0.70) ITGB3ITGAVITGA2B
SCHEMBL7983016 0.78 ITGB3 (0.42) ITGB3ITGAVITGA2BCTSLCTSS
SCHEMBL7983022 0.78 ITGB3 (0.42) ITGB3ITGAVITGA2BCTSLCTSS
SCHEMBL3894303 0.77 ITGB3 (0.35) ITGB3ITGAVITGA2BIDO1TDO2
SCHEMBL7211492 0.76 ITGB3 (0.53) ITGB3ITGAVITGA2B
SCHEMBL7983029 0.75 ITGB3 (0.59) ITGB3ITGAVITGA2B
SCHEMBL7211331 0.75 ITGB3 (0.66) ITGB3ITGAVITGA2BIDO1TDO2
SCHEMBL6704291 0.75 CTSB (0.38) ITGB3ITGAVITGA2BCTSLCTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1995014008-A1 SUBSTITUTED 5-RING HETEROCYCLES, THEIR PREPARATION AND THEIR USE HOECHST AKTIENGESELLSCHAFT (DE) 1995-05-26 WO disclosed