Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.49 |
| ▸ | PPIA | P62937 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26742261 | 0.83 | HTT (0.56) | HTTSMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL11833609 | 0.80 | HTT (0.68) | HTTSMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL7440301 | 0.79 | MEN1 (0.60) | HTTSMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL6797722 | 0.79 | CDC25B (0.63) | HTTSMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL8693048 | 0.78 | ELANE (0.52) | HTTSMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL8689929 | 0.78 | LMNA (0.69) | HTTSMN1; SMN2KDM4EMAPTLMNA | |
| SCHEMBL11790155 | 0.77 | KMT2A (0.69) | HTTSMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL10378109 | 0.77 | HTT (0.54) | HTTSMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL11830768 | 0.76 | DHODH (0.56) | HTTSMN1; SMN2RAB9ANPC1MAPT | |
| SCHEMBL6797565 | 0.75 | MAPT (0.78) | HTTSMN1; SMN2RAB9ANPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037345-A | Method for inhibiting neoplastic cells and related conditions by exposure to quinazolinedione and pyridopyrimidinedione derivatives | CELL PATHWAYS, INC. (US) | 2000-03-14 | — | — | US | disclosed |
| EP-0260817-B1 | QUINAZOLINEDIONES AND PYRIDOPYRIMIDINEDIONES | PFIZER INC. (US) | 1991-05-15 | — | — | EP | disclosed |
| US-4880810-A | Quinazolinediones and pyridopyrimidinediones | PFIZER INC. (US) | 1989-11-14 | — | — | US | disclosed |
| US-4797403-A | Quinazolinediones and pyridopyrimidinediones | PFIZER INC. (US) | 1989-01-10 | — | — | US | disclosed |
| EP-0260817-A1 | Quinazolinediones and pyridopyrimidinediones | PFIZER INC. (US) | 1988-03-23 | — | — | EP | disclosed |
| WO-1988001270-A1 | PYRIDOPYRIMIDINEDIONES | PFIZER INC. (US) | 1988-02-25 | — | — | WO | disclosed |