Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.51 |
| ▸ | YAP1 | P46937 | 3/20 | 0.50 |
| ▸ | ACE | P12821 | 1/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | PSMB10 | P40306 | 4/20 | 0.47 |
| ▸ | REN | P00797 | 1/20 | 0.46 |
| ▸ | PSMB1 | P20618 | 7/20 | 0.46 |
| ▸ | PSMB9 | P28065 | 6/20 | 0.46 |
| ▸ | PSMB5 | P28074 | 6/20 | 0.46 |
| ▸ | PSMB8 | P28062 | 5/20 | 0.46 |
| ▸ | PSMB2 | P49721 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5403799 | 0.91 | CTSS (0.53) | ACE | |
| SCHEMBL5412133 | 0.80 | PPARA (0.59) | ACE | |
| SCHEMBL193474 | 0.80 | PTPN1 (0.73) | BCL2PTPN1YAP1ACEITGB3 | |
| SCHEMBL193473 | 0.80 | PTPN1 (0.73) | BCL2PTPN1YAP1ACEITGB3 | |
| SCHEMBL2891538 | 0.80 | PTPN1 (0.73) | BCL2PTPN1YAP1ACEITGB3 | |
| SCHEMBL5347955 | 0.80 | BCL2 (0.59) | BCL2PTPN1YAP1ITGB3ITGA2B | |
| SCHEMBL5347958 | 0.80 | BCL2 (0.59) | BCL2PTPN1YAP1ITGB3ITGA2B | |
| SCHEMBL6597802 | 0.80 | BCL2 (0.59) | BCL2PTPN1YAP1ITGB3ITGA2B | |
| SCHEMBL5833633 | 0.79 | MME (0.44) | YAP1ACE | |
| SCHEMBL7446328 | 0.79 | AKT1 (0.60) | BCL2PTPN1YAP1ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6323243-B1 | AROMATIC ETHER WITH AMINE OR AMIDE GROUPS | WARNER-LAMBERT COMPANY | 2001-11-27 | — | — | US | disclosed |
| US-6180677-B1 | ANTIEPILEPSY AGENT | WARNER-LAMBERT COMPANY | 2001-01-30 | — | — | US | disclosed |
| WO-2000006535-A1 | TYROSINE-DERIVED COMPOUNDS AS CALCIUM CHANNEL ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |