Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.69 |
| ▸ | GLA | P06280 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | SPR | P35270 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9585876 | 0.79 | HPGD (0.59) | HPGDNPC1GLAKMT2AMEN1 | |
| SCHEMBL4095413 | 0.79 | CCR5 (0.46) | HPGDNPC1GLAKDM4EMAPT | |
| SCHEMBL1777672 | 0.79 | LMNA (0.71) | HPGDKMT2AKDM4EMAPK14SPR | |
| SCHEMBL6807257 | 0.79 | NPC1 (0.69) | HPGDNPC1GLAKMT2AMEN1 | |
| SCHEMBL13198827 | 0.77 | NPC1 (0.67) | HPGDNPC1GLAKMT2AMEN1 | |
| SCHEMBL6356691 | 0.77 | HPGD (0.73) | HPGDNPC1GLAKMT2AMEN1 | |
| SCHEMBL23064287 | 0.76 | GAA (0.67) | HPGDNPC1GLAKMT2AMEN1 | |
| SCHEMBL3758796 | 0.76 | NPC1 (0.65) | HPGDNPC1GLAKMT2AMEN1 | |
| SCHEMBL7311576 | 0.76 | RAB9A (0.69) | HPGDNPC1GLAKMT2AMEN1 | |
| SCHEMBL3758799 | 0.75 | NPC1 (0.63) | HPGDNPC1GLAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4499100-A | CARDIOUVASCULAR DISORDERS | SYNTEX (U.S.A.) INC. (US) | 1985-02-12 | — | — | US | disclosed |