Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.46 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3029893 | 0.80 | MAPT (0.50) | MAPK1MAPTGAAALOX15MEN1 | |
| SCHEMBL7353383 | 0.78 | LMNA (0.49) | MAPK1MAPTGAAALOX15MEN1 | |
| SCHEMBL7026143 | 0.77 | MEN1 (0.44) | MAPK1MAPTGAAALOX15MEN1 | |
| SCHEMBL9367320 | 0.75 | ALDH1A1 (0.35) | GAAMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL7442172 | 0.75 | MEN1 (0.69) | MAPK1MAPTGAAALOX15MEN1 | |
| SCHEMBL3023896 | 0.72 | MAPT (0.49) | MAPK1MAPTGAAALOX15MEN1 | |
| SCHEMBL7167114 | 0.72 | MAPT (0.60) | MAPK1MAPTGAAALOX15MEN1 | |
| SCHEMBL7442632 | 0.72 | MAPK1 (0.50) | MAPK1MAPTGAAALOX15MEN1 | |
| SCHEMBL988 | 0.71 | MAPT (0.50) | MAPK1MAPTGAAALOX15MEN1 | |
| SCHEMBL7160571 | 0.71 | MAPT (0.55) | MAPK1MAPTGAAALOX15MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5734053-A | CARDIOVASCULAR DISORDERS, HYPOTENSIVE AGENTS | PFIZER INC (US) | 1998-03-31 | — | — | US | disclosed |
| EP-0647227-B1 | PURINONE ANTIANGINAL AGENTS | PFIZER LTD (GB) | 1996-10-09 | — | — | EP | disclosed |
| EP-0647227-A1 | PURINONE ANTIANGINAL AGENTS. | PFIZER LTD (GB) | 1995-04-12 | — | — | EP | disclosed |
| WO-1994000453-A1 | PURINONE ANTIANGINAL AGENTS | PFIZER LIMITED (GB) | 1994-01-06 | — | — | WO | disclosed |