Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6177281 | 0.78 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2KDM4EMAPTL3MBTL1 | |
| SCHEMBL23926326 | 0.77 | SIGMAR1 (0.79) | TSHRSIGMAR1HRH3KCNH2 | |
| SCHEMBL30118894 | 0.77 | SIGMAR1 (0.79) | TSHRSIGMAR1HRH3KCNH2 | |
| SCHEMBL6180224 | 0.74 | LTA4H (0.47) | SMN1; SMN2KDM4ESLC6A4HTR1AKCNH2 | |
| Hydrochloric Acid SCHEMBL9644987 | 0.74 | KCNH2 (0.80) | SIGMAR1HRH3KCNH2 | |
| SCHEMBL21587706 | 0.73 | KDM4E (0.64) | ALDH1A1TSHRSMN1; SMN2KDM4EMAPT | |
| SCHEMBL13110052 | 0.73 | SLC6A4 (0.66) | ALDH1A1KDM4ESIGMAR1SLC6A4HRH3 | |
| SCHEMBL15143993 | 0.73 | SMN1; SMN2 (0.54) | TSHRSMN1; SMN2KDM4ESIGMAR1HRH3 | |
| SCHEMBL11365451 | 0.71 | ALDH1A1 (0.55) | ALDH1A1TSHRSMN1; SMN2NPSR1KDM4E | |
| SCHEMBL9069989 | 0.71 | SIGMAR1 (0.77) | SMN1; SMN2SIGMAR1HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025090-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2000-11-08 | — | — | EP | disclosed |
| EP-1025090-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2000-08-09 | — | — | EP | disclosed |
| WO-1999015508-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-04-01 | — | — | WO | disclosed |