Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.48 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5109530 | 0.88 | AGTR1 (0.48) | AGTR1AGTR2RPS6KA5RAB9AMEN1 | |
| Bromide SCHEMBL5929370 | 0.87 | AGTR1 (0.47) | AGTR1AGTR2RPS6KA5RAB9AMEN1 | |
| SCHEMBL13872476 | 0.80 | CYP11B2 (0.49) | AGTR1AGTR2CYP11B2CYP11B1RPS6KA5 | |
| SCHEMBL7019632 | 0.79 | CYP11B2 (0.47) | CYP11B2CYP11B1RAB9AMEN1KMT2A | |
| SCHEMBL3059715 | 0.78 | MEN1 (0.64) | RAB9AMEN1KMT2APKMTP53 | |
| Hydrochloric Acid SCHEMBL7015191 | 0.78 | CYP11B2 (0.46) | CYP11B2CYP11B1RAB9AMEN1KMT2A | |
| SCHEMBL28952848 | 0.75 | AGTR1 (0.38) | AGTR1AGTR2CYP11B2CYP11B1RPS6KA5 | |
| SCHEMBL5096807 | 0.73 | AGTR1 (0.46) | AGTR1AGTR2RPS6KA5RAB9AMEN1 | |
| SCHEMBL7745377 | 0.73 | TSHR (0.50) | AGTR1AGTR2 | |
| SCHEMBL13274084 | 0.73 | PPARG (0.47) | RAB9AKMT2ATP53ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165557-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059905-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2000-10-12 | — | — | WO | disclosed |