Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | KDM6B | O15054 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6642138 | 0.82 | CHEK1 (0.42) | IDO1 | |
| SCHEMBL3926717 | 0.81 | KDM4E (0.35) | — | |
| SCHEMBL6634987 | 0.81 | KAT2B (0.39) | — | |
| SCHEMBL6639588 | 0.78 | FERMT2 (0.37) | — | |
| SCHEMBL7112341 | 0.77 | PDE3B (0.38) | IDO1TRPA1 | |
| SCHEMBL1818357 | 0.74 | — | — | |
| SCHEMBL29159523 | 0.73 | ALDH1A1 (0.35) | — | |
| SCHEMBL27762751 | 0.73 | — | — | |
| SCHEMBL6637172 | 0.73 | — | — | |
| SCHEMBL6233644 | 0.72 | PSIP1 (0.50) | IDO1TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1165557-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2002-01-02 | — | — | EP | disclosed |
| WO-2000059905-A1 | ARYL AND HETEROARYL FUSED AMINOALKYL-IMIDAZOLE DERIVATIVES: SELECTIVE MODULATORS OF GABAa RECEPTORS | NEUROGEN CORPORATION (US) | 2000-10-12 | — | — | WO | disclosed |