Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 6/20 | 0.69 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.69 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.69 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | DRD4 | P21917 | 3/20 | 0.49 |
| ▸ | DRD3 | P35462 | 3/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 4/20 | 0.46 |
| ▸ | OXTR | P30559 | 1/20 | 0.46 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3073412 | 0.84 | OPRL1 (0.60) | OPRL1OPRM1OPRK1CHRM3DRD2 | |
| SCHEMBL181682 | 0.82 | OPRM1 (1.00) | OPRL1OPRM1OPRK1 | |
| SCHEMBL13801271 | 0.79 | OXTR (0.46) | OPRL1OPRM1OPRK1OXTRAVPR1A | |
| SCHEMBL3959841 | 0.78 | OXTR (0.53) | OXTRAVPR1A | |
| SCHEMBL5768740 | 0.76 | HTR2C (0.48) | OPRL1OPRM1OPRK1OXTRAVPR1A | |
| SCHEMBL14486768 | 0.76 | OPRM1 (0.52) | OPRL1OPRM1OPRK1OXTRAVPR1A | |
| SCHEMBL14410177 | 0.76 | OXTR (0.47) | OPRL1OPRM1OPRK1OXTRAVPR1A | |
| SCHEMBL1859464 | 0.75 | OPRL1 (0.86) | OPRL1OPRM1OPRK1 | |
| SCHEMBL13651197 | 0.75 | OPRL1 (0.87) | OPRL1OPRM1OPRK1DRD2DRD4 | |
| SCHEMBL7902547 | 0.75 | OPRL1 (0.56) | OPRL1OPRM1OPRK1CHRM3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714299-B1 | BENZOXAZINONE AND BENZOPYRIMIDINONE PIPERIDINYL TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2002-04-24 | — | — | EP | disclosed |
| US-5767118-A | 4-Heterocyclic peperidines promote release of growth hormone | MERCK & CO., INC. (US) | 1998-06-16 | — | — | US | disclosed |
| EP-0785784-A4 | 4-HETEROCYCLIC PIPERIDINES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO INC (US) | 1998-03-11 | — | — | EP | disclosed |
| US-5665719-A | Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists | MERCK & CO., INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0785784-A1 | 4-HETEROCYCLIC PIPERIDINES PROMOTE RELEASE OF GROWTH HORMONE | Merck & Co., Inc. (US) | 1997-07-30 | — | — | EP | disclosed |
| EP-0714299-A4 | — | — | 1996-07-10 | — | — | EP | disclosed |
| EP-0714299-A1 | BENZOXAZINONE AND BENZOPYRIMIDINONE PIPERIDINYL TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS | MERCK & CO. INC. (US) | 1996-06-05 | — | — | EP | disclosed |
| WO-1996013265-A1 | 4-HETEROCYCLIC PIPERIDINES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1996-05-09 | — | — | WO | disclosed |
| WO-1995002405-A1 | BENZOXAZINONE AND BENZOPYRIMIDINONE PIPERIDINYL TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1995-01-26 | — | — | WO | disclosed |
| EP-0029707-B1 | NOVEL PIPERIDINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | KYOWA HAKKO KOGYO CO., LTD (JP) | 1984-02-01 | — | — | EP | disclosed |
| US-4344948-A | HYPOTENSIVE AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1982-08-17 | — | — | US | disclosed |
| EP-0029707-A1 | Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1981-06-03 | — | — | EP | disclosed |