Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 4/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.56 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.54 |
| ▸ | ACHE | P22303 | 4/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.48 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | DRD4 | P21917 | 4/20 | 0.47 |
| ▸ | DRD3 | P35462 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15847630 | 0.80 | DRD2 (0.68) | OPRL1OPRM1OPRK1CHRM3ACHE | |
| SCHEMBL7012612 | 0.78 | HTR2C (0.45) | OPRL1OPRM1OPRK1DRD2MAPT | |
| SCHEMBL250673 | 0.77 | ACHE (0.69) | OPRL1OPRM1OPRK1CHRM3ACHE | |
| SCHEMBL7447387 | 0.75 | OPRL1 (0.69) | OPRL1OPRM1OPRK1CHRM3ACHE | |
| SCHEMBL1861204 | 0.75 | OPRM1 (0.55) | OPRL1OPRM1OPRK1CHRM3ACHE | |
| SCHEMBL1861203 | 0.75 | OPRM1 (0.55) | OPRL1OPRM1OPRK1CHRM3ACHE | |
| SCHEMBL14450288 | 0.74 | OPRL1 (0.64) | OPRL1OPRM1OPRK1CHRM3ACHE | |
| SCHEMBL5328133 | 0.74 | OPRL1 (0.49) | OPRL1OPRM1OPRK1CHRM3ACHE | |
| SCHEMBL13016528 | 0.73 | ACHE (0.67) | OPRL1OPRM1OPRK1CHRM3ACHE | |
| SCHEMBL3075361 | 0.73 | OPRL1 (0.66) | OPRL1OPRM1OPRK1CHRM3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313097-B1 | TREATMENT OR PROPHYLAXIS OF MIGRAINE OR CLUSTER HEADACHES, NON-INSULIN-DEPENDENT DIABETES MELLITUS, INFLAMMATION, ALLERGIC RHINITIS, ASTHMA, MORPHINE TOLERANCE, MENOPAUSAL HOT FLASHES, DISEASES CHARACTERIZED BY EXCESSIVE VASODILATATION | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-11-06 | — | — | US | disclosed |